{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["30(1)"],"submitter":["Li Y"],"funding":["National Natural Science Foundation of China"],"pubmed_abstract":["The protein-coding ability of circular RNAs (circRNAs) has recently been a hot topic, but the expression and roles of protein-coding circRNAs in triple-negative breast cancer (TNBC) remain uncertain. By intersecting circRNA sequencing data from clinical samples and cell lines, we identified a circRNA, termed circ-EIF6, which predicted a poorer prognosis and correlated with clinicopathological characteristics in a cohort of TNBC patients. Functionally, we showed that circ-EIF6 promoted the proliferation and metastasis of TNBC cells in vitro and in vivo. Mechanistically, we found that circ-EIF6 contains a 675-nucleotide (nt) open reading frame (ORF) and that the -150-bp sequence from ATG functioned as an internal ribosome entry site (IRES), which is required for translation initiation in 5' "],"journal":["Molecular therapy : the journal of the American Society of Gene Therapy"],"pagination":["415-430"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8753373"],"repository":["biostudies-literature"],"pubmed_title":["circ-EIF6 encodes EIF6-224aa to promote TNBC progression via stabilizing MYH9 and activating the Wnt/beta-catenin pathway."],"pmcid":["PMC8753373"],"pubmed_authors":["Yang J","Liang Y","Zhang H","Zhao W","Chen B","Wang L","Liu Y","Li Y","Li Z","Su P","Wang X","Yang Q","Song X","Wang Z","Han D"],"additional_accession":[]},"is_claimable":false,"name":"circ-EIF6 encodes EIF6-224aa to promote TNBC progression via stabilizing MYH9 and activating the Wnt/beta-catenin pathway.","description":"The protein-coding ability of circular RNAs (circRNAs) has recently been a hot topic, but the expression and roles of protein-coding circRNAs in triple-negative breast cancer (TNBC) remain uncertain. By intersecting circRNA sequencing data from clinical samples and cell lines, we identified a circRNA, termed circ-EIF6, which predicted a poorer prognosis and correlated with clinicopathological characteristics in a cohort of TNBC patients. Functionally, we showed that circ-EIF6 promoted the proliferation and metastasis of TNBC cells in vitro and in vivo. Mechanistically, we found that circ-EIF6 contains a 675-nucleotide (nt) open reading frame (ORF) and that the -150-bp sequence from ATG functioned as an internal ribosome entry site (IRES), which is required for translation initiation in 5' ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-04T10:59:10.301Z","creation":"2025-04-04T10:59:10.301Z"},"accession":"S-EPMC8753373","cross_references":{"pubmed":["34450253"],"doi":["10.1016/j.ymthe.2021.08.026"]}}