{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sacheck JM"],"funding":["NHLBI NIH HHS","National Heart, Lung, and Blood Institute","NIH"],"pagination":["73-82"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8755037"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["115(1)"],"pubmed_abstract":["<h4>Background</h4>There remains a lack of evidence demonstrating a potential relationship between vitamin D and cardiometabolic risk among children.<h4>Objectives</h4>We examined the effect of 3 different dosages of vitamin D on cardiometabolic risk factors among children at risk of deficiency.<h4>Methods</h4>Racially diverse schoolchildren aged 8-15 y were randomly assigned in a double-blind fashion to supplementation with 600, 1000, or 2000 IU vitamin D3/d for 6 mo. Changes in HDL cholesterol, triglycerides, LDL cholesterol, total cholesterol, and blood glucose over 6 mo and at 12 mo (6 mo post-supplementation) were assessed. Subgroup analyses were also performed by weight status and race.<h4>Results</h4>Among 604 children, 40.9% were vitamin D-inadequate at baseline (<20 ng/mL; mean ± "],"journal":["The American journal of clinical nutrition"],"pubmed_title":["Vitamin D supplementation and cardiometabolic risk factors among diverse schoolchildren: a randomized clinical trial."],"pmcid":["PMC8755037"],"funding_grant_id":["R01HL106160","R01 HL106160"],"pubmed_authors":["Goodman E","Chomitz VR","Gordon CM","Eliasziw M","Huang Q","Sacheck JM","Van Rompay MI","Economos CD"],"additional_accession":[]},"is_claimable":false,"name":"Vitamin D supplementation and cardiometabolic risk factors among diverse schoolchildren: a randomized clinical trial.","description":"<h4>Background</h4>There remains a lack of evidence demonstrating a potential relationship between vitamin D and cardiometabolic risk among children.<h4>Objectives</h4>We examined the effect of 3 different dosages of vitamin D on cardiometabolic risk factors among children at risk of deficiency.<h4>Methods</h4>Racially diverse schoolchildren aged 8-15 y were randomly assigned in a double-blind fashion to supplementation with 600, 1000, or 2000 IU vitamin D3/d for 6 mo. Changes in HDL cholesterol, triglycerides, LDL cholesterol, total cholesterol, and blood glucose over 6 mo and at 12 mo (6 mo post-supplementation) were assessed. Subgroup analyses were also performed by weight status and race.<h4>Results</h4>Among 604 children, 40.9% were vitamin D-inadequate at baseline (<20 ng/mL; mean ± ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2026-06-01T02:16:46.631Z","creation":"2025-04-19T04:24:45.276Z"},"accession":"S-EPMC8755037","cross_references":{"pubmed":["34550329"],"doi":["10.1093/ajcn/nqab319"]}}