biostudies-literatureSacheck JMNHLBI NIH HHSNational Heart, Lung, and Blood InstituteNIH73-82https://www.ebi.ac.uk/biostudies/studies/S-EPMC8755037biostudies-literatureUnknown115(1)<h4>Background</h4>There remains a lack of evidence demonstrating a potential relationship between vitamin D and cardiometabolic risk among children.<h4>Objectives</h4>We examined the effect of 3 different dosages of vitamin D on cardiometabolic risk factors among children at risk of deficiency.<h4>Methods</h4>Racially diverse schoolchildren aged 8-15 y were randomly assigned in a double-blind fashion to supplementation with 600, 1000, or 2000 IU vitamin D3/d for 6 mo. Changes in HDL cholesterol, triglycerides, LDL cholesterol, total cholesterol, and blood glucose over 6 mo and at 12 mo (6 mo post-supplementation) were assessed. Subgroup analyses were also performed by weight status and race.<h4>Results</h4>Among 604 children, 40.9% were vitamin D-inadequate at baseline (<20 ng/mL; mean ± The American journal of clinical nutritionVitamin D supplementation and cardiometabolic risk factors among diverse schoolchildren: a randomized clinical trial.PMC8755037R01HL106160R01 HL106160Goodman EChomitz VRGordon CMEliasziw MHuang QSacheck JMVan Rompay MIEconomos CDfalseVitamin D supplementation and cardiometabolic risk factors among diverse schoolchildren: a randomized clinical trial.<h4>Background</h4>There remains a lack of evidence demonstrating a potential relationship between vitamin D and cardiometabolic risk among children.<h4>Objectives</h4>We examined the effect of 3 different dosages of vitamin D on cardiometabolic risk factors among children at risk of deficiency.<h4>Methods</h4>Racially diverse schoolchildren aged 8-15 y were randomly assigned in a double-blind fashion to supplementation with 600, 1000, or 2000 IU vitamin D3/d for 6 mo. Changes in HDL cholesterol, triglycerides, LDL cholesterol, total cholesterol, and blood glucose over 6 mo and at 12 mo (6 mo post-supplementation) were assessed. Subgroup analyses were also performed by weight status and race.<h4>Results</h4>Among 604 children, 40.9% were vitamin D-inadequate at baseline (<20 ng/mL; mean ± 2022-01-01T00:00:00Z2022 Jan2026-06-01T02:16:46.631Z2025-04-19T04:24:45.276ZS-EPMC87550373455032910.1093/ajcn/nqab319