{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(24)"],"submitter":["Ouyang L"],"pubmed_abstract":["<h4>Background</h4>Pancreatic cancer (PC) can be considered a representative cancer type of the human body. As demonstrated by some studies, microRNA (miR)-499 is dysregulated in various cancer types including PC, for which chemotherapy involving 5-fluorouracil (5-FU) has long been considered the first-line therapy. However, there are complex and comprehensive mechanisms related to 5-FU, which have not been fully elucidated. This study thus aimed to examine the molecular mechanisms of 5-FU resistance through miR-499a-5p in PC.<h4>Methods</h4>The expression of miR-499a-5p in PC was measured using quantitative polymerase chain reaction (PCR). MiR-499a-5p was examined <i>in-vivo</i> for its effects on the malignant phenotypes of PC cells.<h4>Results</h4>The results of the present study demons"],"journal":["Annals of translational medicine"],"pagination":["1798"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8756217"],"repository":["biostudies-literature"],"pubmed_title":["MiR-499a-5p promotes 5-FU resistance and the cell proliferation and migration through activating PI3K/Akt signaling by targeting PTEN in pancreatic cancer."],"pmcid":["PMC8756217"],"pubmed_authors":["Shang QC","Lei DQ","Jin G","Zheng H","Liu RD","Ouyang L","Li HF","Hu XG"],"additional_accession":[]},"is_claimable":false,"name":"MiR-499a-5p promotes 5-FU resistance and the cell proliferation and migration through activating PI3K/Akt signaling by targeting PTEN in pancreatic cancer.","description":"<h4>Background</h4>Pancreatic cancer (PC) can be considered a representative cancer type of the human body. As demonstrated by some studies, microRNA (miR)-499 is dysregulated in various cancer types including PC, for which chemotherapy involving 5-fluorouracil (5-FU) has long been considered the first-line therapy. However, there are complex and comprehensive mechanisms related to 5-FU, which have not been fully elucidated. This study thus aimed to examine the molecular mechanisms of 5-FU resistance through miR-499a-5p in PC.<h4>Methods</h4>The expression of miR-499a-5p in PC was measured using quantitative polymerase chain reaction (PCR). MiR-499a-5p was examined <i>in-vivo</i> for its effects on the malignant phenotypes of PC cells.<h4>Results</h4>The results of the present study demons","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-20T00:39:41.666Z","creation":"2025-02-19T03:29:20.583Z"},"accession":"S-EPMC8756217","cross_references":{"pubmed":["35071492"],"doi":["10.21037/atm-21-6556"]}}