{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gaafer OU"],"funding":["National Institute of Arthritis and Musculoskeletal and Skin Diseases","BLRD VA","National Cancer Institute","NCI NIH HHS","NIAMS NIH HHS","U.S. Department of Veterans Affairs","National Institute of General Medical Sciences","NIGMS NIH HHS","CSRD VA"],"pagination":["16-25"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8756772"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["45(S2)"],"pubmed_abstract":["Cancer cachexia, or progressive weight loss, often despite adequate nutrition contributes greatly to cancer morbidity and mortality. Cachexia is metabolically distinct from starvation or protein malnutrition, although many patients with cancer and cachexia exhibit lowered appetite and food consumption. Tumors affect neural mechanisms that regulate appetite and energy expenditure, while promoting wasting of peripheral tissues via catabolism of cardiac and skeletal muscle, adipose, and bone. These multimodal actions of tumors on the host suggest a need for multimodal interventions. However, multiple recent consensus guidelines for management of cancer cachexia differ in treatment recommendations, highlighting the lack of effective, available therapies. Challenges to defining appropriate nutr"],"journal":["JPEN. Journal of parenteral and enteral nutrition"],"pubmed_title":["Nutrition challenges of cancer cachexia."],"pmcid":["PMC8756772"],"funding_grant_id":["P30AR072581","R01GM137656","P01CA236778","P30CA082709","R01 GM137656","P01 CA236778","I01BX004177","I01CX002046","I01 BX004177","R21 AR074908","I01 CX002046","P30 CA082709","P30 AR072581"],"pubmed_authors":["Gaafer OU","Zimmers TA"],"additional_accession":[]},"is_claimable":false,"name":"Nutrition challenges of cancer cachexia.","description":"Cancer cachexia, or progressive weight loss, often despite adequate nutrition contributes greatly to cancer morbidity and mortality. Cachexia is metabolically distinct from starvation or protein malnutrition, although many patients with cancer and cachexia exhibit lowered appetite and food consumption. Tumors affect neural mechanisms that regulate appetite and energy expenditure, while promoting wasting of peripheral tissues via catabolism of cardiac and skeletal muscle, adipose, and bone. These multimodal actions of tumors on the host suggest a need for multimodal interventions. However, multiple recent consensus guidelines for management of cancer cachexia differ in treatment recommendations, highlighting the lack of effective, available therapies. Challenges to defining appropriate nutr","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2025-04-04T22:33:46.952Z","creation":"2025-02-19T03:24:01.095Z"},"accession":"S-EPMC8756772","cross_references":{"pubmed":["34897740"],"doi":["10.1002/jpen.2287"]}}