{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Prajna NV"],"funding":["NEI NIH HHS"],"pagination":["179-184"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8759027"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["140(2)"],"pubmed_abstract":["<h4>Importance</h4>Antifungal resistance has been shown to impact treatment success, but research analyzing antifungal resistance is scarce.<h4>Objective</h4>To evaluate changes in antifungal resistance over time.<h4>Design, setting, and participants</h4>Ad hoc analysis of 3 randomized clinical trials including consecutive patients 18 years and older presenting with smear-positive fungal ulcers to Aravind Eye Hospitals in Madurai, Coimbatore, Pondicherry, and Tirunelveli in South India who participated in 1 of 3 clinical trials: the Mycotic Ulcer Treatment Trials (MUTT) I (2010 to 2011) or II (2010 to 2015) or the Cross-Linking Assisted Infection Reduction (CLAIR) trial (2016 to 2018). This post hoc analysis was designed in March 2021 and data were analyzed in May and November 2021.<h4>Int"],"journal":["JAMA ophthalmology"],"pubmed_title":["Patterns of Antifungal Resistance in Adult Patients With Fungal Keratitis in South India: A Post Hoc Analysis of 3 Randomized Clinical Trials."],"pmcid":["PMC8759027"],"funding_grant_id":["K23 EY025025","U10 EY018573"],"pubmed_authors":["Rajaraman R","Krishnan T","Srinivasan M","Prajna NV","Lalitha P","Das M","Devi L","Porco TC","Liu Z","Acharya NR","Lietman TM","Rose-Nussbaumer J","Radnakrishnan N","Zegans ME"],"additional_accession":[]},"is_claimable":false,"name":"Patterns of Antifungal Resistance in Adult Patients With Fungal Keratitis in South India: A Post Hoc Analysis of 3 Randomized Clinical Trials.","description":"<h4>Importance</h4>Antifungal resistance has been shown to impact treatment success, but research analyzing antifungal resistance is scarce.<h4>Objective</h4>To evaluate changes in antifungal resistance over time.<h4>Design, setting, and participants</h4>Ad hoc analysis of 3 randomized clinical trials including consecutive patients 18 years and older presenting with smear-positive fungal ulcers to Aravind Eye Hospitals in Madurai, Coimbatore, Pondicherry, and Tirunelveli in South India who participated in 1 of 3 clinical trials: the Mycotic Ulcer Treatment Trials (MUTT) I (2010 to 2011) or II (2010 to 2015) or the Cross-Linking Assisted Infection Reduction (CLAIR) trial (2016 to 2018). This post hoc analysis was designed in March 2021 and data were analyzed in May and November 2021.<h4>Int","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-04T14:29:59.649Z","creation":"2025-04-04T14:29:59.649Z"},"accession":"S-EPMC8759027","cross_references":{"pubmed":["35024776"],"doi":["10.1001/jamaophthalmol.2021.5765"]}}