biostudies-literaturePrajna NVNEI NIH HHS179-184https://www.ebi.ac.uk/biostudies/studies/S-EPMC8759027biostudies-literatureUnknown140(2)<h4>Importance</h4>Antifungal resistance has been shown to impact treatment success, but research analyzing antifungal resistance is scarce.<h4>Objective</h4>To evaluate changes in antifungal resistance over time.<h4>Design, setting, and participants</h4>Ad hoc analysis of 3 randomized clinical trials including consecutive patients 18 years and older presenting with smear-positive fungal ulcers to Aravind Eye Hospitals in Madurai, Coimbatore, Pondicherry, and Tirunelveli in South India who participated in 1 of 3 clinical trials: the Mycotic Ulcer Treatment Trials (MUTT) I (2010 to 2011) or II (2010 to 2015) or the Cross-Linking Assisted Infection Reduction (CLAIR) trial (2016 to 2018). This post hoc analysis was designed in March 2021 and data were analyzed in May and November 2021.<h4>IntJAMA ophthalmologyPatterns of Antifungal Resistance in Adult Patients With Fungal Keratitis in South India: A Post Hoc Analysis of 3 Randomized Clinical Trials.PMC8759027K23 EY025025U10 EY018573Rajaraman RKrishnan TSrinivasan MPrajna NVLalitha PDas MDevi LPorco TCLiu ZAcharya NRLietman TMRose-Nussbaumer JRadnakrishnan NZegans MEfalsePatterns of Antifungal Resistance in Adult Patients With Fungal Keratitis in South India: A Post Hoc Analysis of 3 Randomized Clinical Trials.<h4>Importance</h4>Antifungal resistance has been shown to impact treatment success, but research analyzing antifungal resistance is scarce.<h4>Objective</h4>To evaluate changes in antifungal resistance over time.<h4>Design, setting, and participants</h4>Ad hoc analysis of 3 randomized clinical trials including consecutive patients 18 years and older presenting with smear-positive fungal ulcers to Aravind Eye Hospitals in Madurai, Coimbatore, Pondicherry, and Tirunelveli in South India who participated in 1 of 3 clinical trials: the Mycotic Ulcer Treatment Trials (MUTT) I (2010 to 2011) or II (2010 to 2015) or the Cross-Linking Assisted Infection Reduction (CLAIR) trial (2016 to 2018). This post hoc analysis was designed in March 2021 and data were analyzed in May and November 2021.<h4>Int2022-01-01T00:00:00Z2022 Feb2025-04-04T14:29:59.649Z2025-04-04T14:29:59.649ZS-EPMC87590273502477610.1001/jamaophthalmol.2021.5765