{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rogers-DeCotes AW"],"funding":["NIDCR NIH HHS","NHLBI NIH HHS","American Heart Association Inc","National Institutes of Health"],"pagination":["547-557"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8759092"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(4)"],"pubmed_abstract":["<h4>Objective</h4>Determine the role of the extracellular matrix protease ADAMTS5 in development of the trabeculated bone of the mandibular condyle.<h4>Methods</h4>The mandibular condyles of wild type and mice deficient in the protease ADAMTS5 were examined for histopathology with Safranin O staining. Microcomputed tomography was performed to analyze the developing bone of the mandibular condyle. RNAscope and immunohistochemistry were utilized to investigate cell type and extracellular matrix expression.<h4>Results</h4>Mice deficient in Adamts5, (Adamts5<sup>tm1Dgen/J</sup>) exhibit an increase in trabecular separation (n = 37 wild type; n = 27: P < 0.0001) and reduction of trabecular thickness P = 0.0116 and bone volume fraction P = 0.0869 in the mandibular condylar head compared to wild "],"journal":["Osteoarthritis and cartilage"],"pubmed_title":["ADAMTS5 is required for normal trabeculated bone development in the mandibular condyle."],"pmcid":["PMC8759092"],"funding_grant_id":["R01 HL121382","F30 DE028180","T32 DE017551"],"pubmed_authors":["Rogers-DeCotes AW","Kern CB","Porto SC","Dupuis LE"],"additional_accession":[]},"is_claimable":false,"name":"ADAMTS5 is required for normal trabeculated bone development in the mandibular condyle.","description":"<h4>Objective</h4>Determine the role of the extracellular matrix protease ADAMTS5 in development of the trabeculated bone of the mandibular condyle.<h4>Methods</h4>The mandibular condyles of wild type and mice deficient in the protease ADAMTS5 were examined for histopathology with Safranin O staining. Microcomputed tomography was performed to analyze the developing bone of the mandibular condyle. RNAscope and immunohistochemistry were utilized to investigate cell type and extracellular matrix expression.<h4>Results</h4>Mice deficient in Adamts5, (Adamts5<sup>tm1Dgen/J</sup>) exhibit an increase in trabecular separation (n = 37 wild type; n = 27: P < 0.0001) and reduction of trabecular thickness P = 0.0116 and bone volume fraction P = 0.0869 in the mandibular condylar head compared to wild ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-22T09:18:08.288Z","creation":"2025-04-05T22:58:17.498Z"},"accession":"S-EPMC8759092","cross_references":{"pubmed":["33561540"],"doi":["10.1016/j.joca.2021.01.005"]}}