{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bowers DT"],"funding":["National Institute of Arthritis and Musculoskeletal and Skin Diseases","National Institutes of Health","NIAMS NIH HHS","National Institute of Biomedical Imaging and Bioengineering","NIH HHS"],"pagination":["295-308"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8759537"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(12)"],"pubmed_abstract":["Mechanotransduction arises from information encoded in the shape of materials such as curvature. It induces activation of small GTPase signaling affecting cell phenotypes including differentiation. We carried out a set of preliminary experiments to test the hypothesis that curvature (1/radius) would also affect cell motility due to signal pathway crosstalk. High molecular weight poly (methyl methacrylate) straight nanofibers were electrospun with curvature ranging from 41 to 1 μm-1 and collected on a passivated glass substrate. The fiber curvature increased mouse mesenchymal stem cell aspect ratio (P < 0.02) and decreased cell area (P < 0.01). Despite little effect on some motility patterns such as polarity and persistence, we found selected fiber curvatures can increase normalized random "],"journal":["Integrative biology : quantitative biosciences from nano to macro"],"pubmed_title":["Nanofiber curvature with Rho GTPase activity increases mouse embryonic fibroblast random migration velocity."],"pmcid":["PMC8759537"],"funding_grant_id":["R21EB019230","R03AR065192"],"pubmed_authors":["Brown JL","Bowers DT"],"additional_accession":[]},"is_claimable":false,"name":"Nanofiber curvature with Rho GTPase activity increases mouse embryonic fibroblast random migration velocity.","description":"Mechanotransduction arises from information encoded in the shape of materials such as curvature. It induces activation of small GTPase signaling affecting cell phenotypes including differentiation. We carried out a set of preliminary experiments to test the hypothesis that curvature (1/radius) would also affect cell motility due to signal pathway crosstalk. High molecular weight poly (methyl methacrylate) straight nanofibers were electrospun with curvature ranging from 41 to 1 μm-1 and collected on a passivated glass substrate. The fiber curvature increased mouse mesenchymal stem cell aspect ratio (P < 0.02) and decreased cell area (P < 0.01). Despite little effect on some motility patterns such as polarity and persistence, we found selected fiber curvatures can increase normalized random ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-19T23:07:16.738Z","creation":"2025-04-19T23:07:16.738Z"},"accession":"S-EPMC8759537","cross_references":{"pubmed":["35022716"],"doi":["10.1093/intbio/zyab022"]}}