{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(2)"],"submitter":["Merzkani MA"],"pubmed_abstract":["<h4>Background</h4>Improving both patient and graft survival after kidney transplantation are major unmet needs. The goal of this study was to assess risk factors for specific causes of graft loss to determine to what extent patients who develop either death with a functioning graft (DWFG) or graft failure (GF) have similar baseline risk factors for graft loss.<h4>Methods</h4>We retrospectively studied all solitary renal transplants performed between January 1, 2006, and December 31, 2018, at 3 centers and determined the specific causes of DWFG and GF. We examined outcomes in different subgroups using competing risk estimates and cause-specific Cox models.<h4>Results</h4>Of the 5752 kidney transplants, graft loss occurred in 21.6% (1244) patients, including 12.0% (691) DWFG and 9.6% (553) "],"journal":["Transplantation direct"],"pagination":["e1273"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8759617"],"repository":["biostudies-literature"],"pubmed_title":["Death With Function and Graft Failure After Kidney Transplantation: Risk Factors at Baseline Suggest New Approaches to Management."],"pmcid":["PMC8759617"],"pubmed_authors":["Schinstock CA","Rule AD","Wadei HM","Gandhi MJ","Khamash H","Kukla A","Merzkani MA","Mai M","D'Costa MR","Smith BH","El Ters M","Kremers WK","Chakkera H","Stegall MD","Heilman R","Park WD","Alexander MP","Benavides Lopez X","Reddy K","Issa N","Amer H","Bentall AJ"],"additional_accession":[]},"is_claimable":false,"name":"Death With Function and Graft Failure After Kidney Transplantation: Risk Factors at Baseline Suggest New Approaches to Management.","description":"<h4>Background</h4>Improving both patient and graft survival after kidney transplantation are major unmet needs. The goal of this study was to assess risk factors for specific causes of graft loss to determine to what extent patients who develop either death with a functioning graft (DWFG) or graft failure (GF) have similar baseline risk factors for graft loss.<h4>Methods</h4>We retrospectively studied all solitary renal transplants performed between January 1, 2006, and December 31, 2018, at 3 centers and determined the specific causes of DWFG and GF. We examined outcomes in different subgroups using competing risk estimates and cause-specific Cox models.<h4>Results</h4>Of the 5752 kidney transplants, graft loss occurred in 21.6% (1244) patients, including 12.0% (691) DWFG and 9.6% (553) ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-05T10:53:19.654Z","creation":"2022-02-11T15:31:04.093Z"},"accession":"S-EPMC8759617","cross_references":{"pubmed":["35047660"],"doi":["10.1097/TXD.0000000000001273"]}}