biostudies-literatureWhitaker AANCATS NIH HHSNICHD NIH HHSNIA NIH HHSHHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentHHS | NIH | National Center for Research ResourcesHHS | NIH | National Institute on AgingGeorgia Holland Endowment at University of Kansas Medical CenterHHS | NIH | National Center for Advancing Translational SciencesNIH HHS236-246https://www.ebi.ac.uk/biostudies/studies/S-EPMC8759972biostudies-literatureUnknown132(1)High-intensity interval exercise (HIIT) is performed widely. However, there is a gap in knowledge regarding the acute cerebrovascular response to low-volume HIIT. Our objective was to characterize the middle cerebral artery blood velocity (MCAv) response during an acute bout of low-volume HIIT in young healthy adults. We hypothesized that MCAv would decrease below the baseline (BL), <i>1</i>) during HIIT, <i>2</i>) immediately following HIIT, and <i>3</i>) 30 min after HIIT. As a secondary objective, we investigated sex differences in the MCAv response during HIIT. Twenty-four young healthy adults completed HIIT [12 males, age = 25 (SD = 2)]. HIIT included 10 min of 1-min high intensity (∼70% estimated maximal Watts) and active recovery (10% estimated maximal Watts) intervals on a recumbenJournal of applied physiology (Bethesda, Md. : 1985)Cerebrovascular response to an acute bout of low-volume high-intensity interval exercise and recovery in young healthy adults.PMC8759972T32 HD057850T32HD057850UL1 TR000001P30 AG035982P30 AG072973P30 AG035982-08TL1 TR002368TL1TR002368ULTR000001Aaron SEWhitaker AABillinger SAVidoni EDMontgomery RNKaufman CSBai SXKurtz BKfalseCerebrovascular response to an acute bout of low-volume high-intensity interval exercise and recovery in young healthy adults.High-intensity interval exercise (HIIT) is performed widely. However, there is a gap in knowledge regarding the acute cerebrovascular response to low-volume HIIT. Our objective was to characterize the middle cerebral artery blood velocity (MCAv) response during an acute bout of low-volume HIIT in young healthy adults. We hypothesized that MCAv would decrease below the baseline (BL), <i>1</i>) during HIIT, <i>2</i>) immediately following HIIT, and <i>3</i>) 30 min after HIIT. As a secondary objective, we investigated sex differences in the MCAv response during HIIT. Twenty-four young healthy adults completed HIIT [12 males, age = 25 (SD = 2)]. HIIT included 10 min of 1-min high intensity (∼70% estimated maximal Watts) and active recovery (10% estimated maximal Watts) intervals on a recumben2022-01-01T00:00:00Z2022 Jan2025-04-22T10:11:44.505Z2025-04-05T23:27:22.358ZS-EPMC87599723488202710.1152/japplphysiol.00484.2021