{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Robertson MJ"],"funding":["NINDS NIH HHS","National Institutes of Health","NIGMS NIH HHS"],"pagination":["124-135"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8760134"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["47(2)"],"pubmed_abstract":["Structure-based drug discovery (SBDD) is an indispensable approach for the design and optimization of new therapeutic agents. Here, we highlight the rapid progress that has turned cryo-electron microscopy (cryoEM) into an exceptional SBDD tool, and the wealth of new structural information it is providing for high-value pharmacological targets. We review key advantages of a technique that directly images vitrified biomolecules without the need for crystallization; both in terms of a broader array of systems that can be studied and the different forms of information it can provide, including heterogeneity and dynamics. We discuss near- and far-future developments, working in concert towards achieving the resolution and throughput necessary for cryoEM to make a widespread impact on the SBDD pipeline."],"journal":["Trends in biochemical sciences"],"pubmed_title":["Drug discovery in the era of cryo-electron microscopy."],"pmcid":["PMC8760134"],"funding_grant_id":["R01 NS092695","R01 NS122394","T32 GM089626"],"pubmed_authors":["Skiniotis G","Meyerowitz JG","Robertson MJ"],"additional_accession":[]},"is_claimable":false,"name":"Drug discovery in the era of cryo-electron microscopy.","description":"Structure-based drug discovery (SBDD) is an indispensable approach for the design and optimization of new therapeutic agents. Here, we highlight the rapid progress that has turned cryo-electron microscopy (cryoEM) into an exceptional SBDD tool, and the wealth of new structural information it is providing for high-value pharmacological targets. We review key advantages of a technique that directly images vitrified biomolecules without the need for crystallization; both in terms of a broader array of systems that can be studied and the different forms of information it can provide, including heterogeneity and dynamics. We discuss near- and far-future developments, working in concert towards achieving the resolution and throughput necessary for cryoEM to make a widespread impact on the SBDD pipeline.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-19T14:19:46.417Z","creation":"2025-02-19T04:45:58.078Z"},"accession":"S-EPMC8760134","cross_references":{"pubmed":["34281791"],"doi":["10.1016/j.tibs.2021.06.008"]}}