{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen See JR"],"funding":["NIA NIH HHS","NASA","NHLBI NIH HHS","National Heart, Lung, and Blood Institute","West Virginia Space Grant Consortium","National Institute of General Medical Sciences","National Institute on Aging","NIGMS NIH HHS"],"pagination":["4220-4235"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8761204"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(9)"],"pubmed_abstract":["Exercise influences metabolic parameters in part by modulating redox stress and as recently suggested, by affecting the gut microbiome. However, whether excess endogenous antioxidant potentiates or interferes with the beneficial effects of exercise on the gut microbiome is not known. A comparison of the gut microbiome of C57Bl6 (C57/WT) mice to the 'stress-less' catalase overexpressing mice models ([Tg(CAT)<sup>±</sup> ] and Bob-Cat), that were either exercised or remained sedentary, showed differences in both alpha and beta diversity. The significant variation was explained by genotypes along with exercise, suggesting a synergistic relationship between exercise and genotypic traits. Linear discriminant analysis effect size (LEfSe) analysis also revealed differential taxa within the exerci"],"journal":["Environmental microbiology"],"pubmed_title":["Synergistic effects of exercise and catalase overexpression on gut microbiome."],"pmcid":["PMC8761204"],"funding_grant_id":["R15 AG051062","R01 HL074239","P20 GM103434","5P20GM103434","NNX15AI01H","5R01HL‐074239","1R15AG051062‐01"],"pubmed_authors":["Santanam N","Lamendella R","Wright J","Amos D","Chen See JR"],"additional_accession":[]},"is_claimable":false,"name":"Synergistic effects of exercise and catalase overexpression on gut microbiome.","description":"Exercise influences metabolic parameters in part by modulating redox stress and as recently suggested, by affecting the gut microbiome. However, whether excess endogenous antioxidant potentiates or interferes with the beneficial effects of exercise on the gut microbiome is not known. A comparison of the gut microbiome of C57Bl6 (C57/WT) mice to the 'stress-less' catalase overexpressing mice models ([Tg(CAT)<sup>±</sup> ] and Bob-Cat), that were either exercised or remained sedentary, showed differences in both alpha and beta diversity. The significant variation was explained by genotypes along with exercise, suggesting a synergistic relationship between exercise and genotypic traits. Linear discriminant analysis effect size (LEfSe) analysis also revealed differential taxa within the exerci","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-25T20:19:23.661Z","creation":"2025-04-06T08:21:21.805Z"},"accession":"S-EPMC8761204","cross_references":{"pubmed":["34270161"],"doi":["10.1111/1462-2920.15670"]}}