{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Guille C"],"funding":["Office of Research on Womens Health","NIDA NIH HHS","National Institute on Drug Abuse"],"pagination":["106616"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8761253"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["111"],"pubmed_abstract":["Opioid Use Disorders (OUDs) and drug overdose deaths are increasing at alarmingly high rates in the United States. Stress and dysregulation in biologic stress response systems such as the hypothalamic-pituitary-adrenal axis and noradrenergic system appear to play an important role in the pathophysiology of substance use disorders and relapse to drug use, particularly for women. Alpha-2 adrenergic agonist medications effectively decrease noradrenergic activity and have demonstrated benefit in preventing relapse to substance use and decreasing stress-reactivity and craving in cocaine- and nicotine-dependent women, compared to men. Alpha-2 adrenergic agonists may help decrease stress reactivity in individuals with OUDs and prevent relapse to drug use, but gender differences have yet to be sys"],"journal":["Contemporary clinical trials"],"pubmed_title":["The impact of lofexidine on stress-related opioid craving and relapse: Design and methodology of a randomized clinical trial."],"pmcid":["PMC8761253"],"funding_grant_id":["U54 DA016511"],"pubmed_authors":["Guille C","Cortese B","Baker N","Brady K","McRae-Clark A","King C","Rogers T","Nunn L","Ramakrishnan V"],"additional_accession":[]},"is_claimable":false,"name":"The impact of lofexidine on stress-related opioid craving and relapse: Design and methodology of a randomized clinical trial.","description":"Opioid Use Disorders (OUDs) and drug overdose deaths are increasing at alarmingly high rates in the United States. Stress and dysregulation in biologic stress response systems such as the hypothalamic-pituitary-adrenal axis and noradrenergic system appear to play an important role in the pathophysiology of substance use disorders and relapse to drug use, particularly for women. Alpha-2 adrenergic agonist medications effectively decrease noradrenergic activity and have demonstrated benefit in preventing relapse to substance use and decreasing stress-reactivity and craving in cocaine- and nicotine-dependent women, compared to men. Alpha-2 adrenergic agonists may help decrease stress reactivity in individuals with OUDs and prevent relapse to drug use, but gender differences have yet to be sys","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-19T15:39:57.773Z","creation":"2025-04-19T15:39:57.773Z"},"accession":"S-EPMC8761253","cross_references":{"pubmed":["34737091"],"doi":["10.1016/j.cct.2021.106616"]}}