biostudies-literatureGurgel MCoordination for the Improvement of Higher Education PersonnelNIDCR NIH HHSNational Institute of Dental and Craniofacial ResearchNational Institute of Dental and Craniofacial Research (US)Department of Radiology and Biomedical Imaging, University of California, San Francisco875-887https://www.ebi.ac.uk/biostudies/studies/S-EPMC8761785biostudies-literatureUnknown26(1)<h4>Objectives</h4>This study aims to assess craniofacial dimensions in obstructive sleep apnea (OSA) patients treated with a mandibular advancement device (MAD) and to identify anatomic influences on OSA severity and MAD therapy outcomes.<h4>Materials and methods</h4>Twenty patients with OSA were prospectively treated with MAD. Clinical, cone-beam computed tomography, and polysomnography exams were performed before treatment and 4-6 months after achieving the MAD therapeutic position. Polysomnographic exams and three-dimensional maxillary, mandibular, and upper airway (UA) measurements were evaluated. Pearson's correlation and t-tests were applied.<h4>Results</h4>Before MAD treatment, the transverse width measured at the frontomaxillary suture and the angle between the mandibular ramus anClinical oral investigationsThree-dimensional craniofacial characteristics associated with obstructive sleep apnea severity and treatment outcomes.PMC8761785R01DE024450R01 DE024450Ruellas ABittencourt LPereira RCunali PGurgel MCevidanes LJunior CCCosta FBianchi JfalseThree-dimensional craniofacial characteristics associated with obstructive sleep apnea severity and treatment outcomes.<h4>Objectives</h4>This study aims to assess craniofacial dimensions in obstructive sleep apnea (OSA) patients treated with a mandibular advancement device (MAD) and to identify anatomic influences on OSA severity and MAD therapy outcomes.<h4>Materials and methods</h4>Twenty patients with OSA were prospectively treated with MAD. Clinical, cone-beam computed tomography, and polysomnography exams were performed before treatment and 4-6 months after achieving the MAD therapeutic position. Polysomnographic exams and three-dimensional maxillary, mandibular, and upper airway (UA) measurements were evaluated. Pearson's correlation and t-tests were applied.<h4>Results</h4>Before MAD treatment, the transverse width measured at the frontomaxillary suture and the angle between the mandibular ramus an2022-01-01T00:00:00Z2022 Jan2025-04-19T18:08:30.812Z2025-04-19T18:08:30.812ZS-EPMC87617853427301210.1007/s00784-021-04066-5