{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kainz A"],"funding":["H2020 Marie Sklodowska-Curie Actions","Vienna Science and Technology Fund"],"pagination":["90-97"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8763155"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["<h4>Background and objectives</h4>The median kidney transplant half-life is 10-15 years. Because of the scarcity of donor organs and immunologic sensitization of candidates for retransplantation, there is a need for quantitative information on if and when a second transplantation is no longer associated with a lower risk of mortality compared with waitlisted patients treated by dialysis. Therefore, we investigated the association of time on waiting list with patient survival in patients who received a second transplantation versus remaining on the waiting list.<h4>Design, setting, participants, & measurements</h4>In this retrospective study using target trial emulation, we analyzed data of 2346 patients from the Austrian Dialysis and Transplant Registry and Eurotransplant with a failed first graft, aged over 18 years, and waitlisted for a second kidney transplantation in Austria during the years 1980-2019. The differences in restricted mean survival time and hazard ratios for all-cause mortality comparing the treatment strategies \"retransplant\" versus \"remain waitlisted with maintenance dialysis\" are reported for different waiting times after first graft loss.<h4>Results</h4>Second kidney transplantation showed a longer restricted mean survival time at 10 years of follow-up compared with remaining on the waiting list (5.8 life months gained; 95% confidence interval, 0.9 to 11.1). This survival difference was diminished in patients with longer waiting time after loss of the first allograft; restricted mean survival time differences at 10 years were 8.0 (95% confidence interval, 1.9 to 14.0) and 0.1 life months gained (95% confidence interval, -14.3 to 15.2) for patients with waiting time for retransplantation of <1 and 8 years, respectively.<h4>Conclusions</h4>Second kidney transplant is associated with patient survival compared with remaining waitlisted and treatment by dialysis, but the survival difference diminishes with longer waiting time."],"journal":["Clinical journal of the American Society of Nephrology : CJASN"],"pubmed_title":["Waiting Time for Second Kidney Transplantation and Mortality."],"pmcid":["PMC8763155"],"funding_grant_id":["LS16-019","795292"],"pubmed_authors":["Reindl-Schwaighofer R","Petr V","Naik M","Strohmaier S","Kainz A","Kammer M","Viklicky O","Mayer G","Oberbauer R","Abramowicz D"],"additional_accession":[]},"is_claimable":false,"name":"Waiting Time for Second Kidney Transplantation and Mortality.","description":"<h4>Background and objectives</h4>The median kidney transplant half-life is 10-15 years. Because of the scarcity of donor organs and immunologic sensitization of candidates for retransplantation, there is a need for quantitative information on if and when a second transplantation is no longer associated with a lower risk of mortality compared with waitlisted patients treated by dialysis. Therefore, we investigated the association of time on waiting list with patient survival in patients who received a second transplantation versus remaining on the waiting list.<h4>Design, setting, participants, & measurements</h4>In this retrospective study using target trial emulation, we analyzed data of 2346 patients from the Austrian Dialysis and Transplant Registry and Eurotransplant with a failed first graft, aged over 18 years, and waitlisted for a second kidney transplantation in Austria during the years 1980-2019. The differences in restricted mean survival time and hazard ratios for all-cause mortality comparing the treatment strategies \"retransplant\" versus \"remain waitlisted with maintenance dialysis\" are reported for different waiting times after first graft loss.<h4>Results</h4>Second kidney transplantation showed a longer restricted mean survival time at 10 years of follow-up compared with remaining on the waiting list (5.8 life months gained; 95% confidence interval, 0.9 to 11.1). This survival difference was diminished in patients with longer waiting time after loss of the first allograft; restricted mean survival time differences at 10 years were 8.0 (95% confidence interval, 1.9 to 14.0) and 0.1 life months gained (95% confidence interval, -14.3 to 15.2) for patients with waiting time for retransplantation of <1 and 8 years, respectively.<h4>Conclusions</h4>Second kidney transplant is associated with patient survival compared with remaining waitlisted and treatment by dialysis, but the survival difference diminishes with longer waiting time.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-21T15:18:16.652Z","creation":"2025-04-21T15:18:16.652Z"},"accession":"S-EPMC8763155","cross_references":{"pubmed":["34965955"],"doi":["10.2215/CJN.07620621","10.2215/cjn.07620621"]}}