{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["107(2)"],"submitter":["Laakso S"],"funding":["Intramural NIH HHS","Novo Nordisk Foundation","Helsinki University Hospital","Regional Health Authorities of Western Norway","National Institutes of Health","Division of Intramural Research, National Institute of Allergy and Infectious Diseases","Academy of Finland","Norwegian Research Council","Stiftelsen Kristian Gerhard Jebsen","University of Bergen","Sigrid Jusélius Foundation","Folkhälsan Research Foundation","Foundation for Pediatric Research"],"pubmed_abstract":["<h4>Context</h4>Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED; also known as autoimmune polyendocrine syndrome type 1) has a severe, unpredictable course. Autoimmunity and disease components may affect fertility and predispose to maternal and fetal complications, but pregnancy outcomes remain unknown.<h4>Objective</h4>To assess fetal and maternal outcomes and course of clinical APECED manifestations during pregnancy in women with APECED.<h4>Design and setting</h4>A multicenter registry-based study including 5 national patient cohorts.<h4>Patients</h4>321 females with APECED.<h4>Main outcome measure</h4>Number of pregnancies, miscarriages, and deliveries.<h4>Results</h4>Forty-three patients had altogether 83 pregnancies at median age of 27 years (range, 17-39). Sixt"],"journal":["The Journal of clinical endocrinology and metabolism"],"pagination":["e528-e537"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8764323"],"repository":["biostudies-literature"],"pubmed_title":["Pregnancy Outcome in Women With APECED (APS-1): A Multicenter Study on 43 Females With 83 Pregnancies."],"pmcid":["PMC8764323"],"pubmed_authors":["Schmitt MM","Kareva M","Husebye ES","Vogt E","Makitie O","Betterle C","Sabbadin C","Saari V","Orlova E","Lionakis MS","Winer KK","Laakso S","Holopainen E"],"additional_accession":[]},"is_claimable":false,"name":"Pregnancy Outcome in Women With APECED (APS-1): A Multicenter Study on 43 Females With 83 Pregnancies.","description":"<h4>Context</h4>Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED; also known as autoimmune polyendocrine syndrome type 1) has a severe, unpredictable course. Autoimmunity and disease components may affect fertility and predispose to maternal and fetal complications, but pregnancy outcomes remain unknown.<h4>Objective</h4>To assess fetal and maternal outcomes and course of clinical APECED manifestations during pregnancy in women with APECED.<h4>Design and setting</h4>A multicenter registry-based study including 5 national patient cohorts.<h4>Patients</h4>321 females with APECED.<h4>Main outcome measure</h4>Number of pregnancies, miscarriages, and deliveries.<h4>Results</h4>Forty-three patients had altogether 83 pregnancies at median age of 27 years (range, 17-39). Sixt","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-20T03:08:33.543Z","creation":"2022-02-11T16:12:01.069Z"},"accession":"S-EPMC8764323","cross_references":{"pubmed":["34570215"],"doi":["10.1210/clinem/dgab705"]}}