biostudies-literatureUnknown107(2)Laakso SIntramural NIH HHSNovo Nordisk FoundationHelsinki University HospitalRegional Health Authorities of Western NorwayNational Institutes of HealthDivision of Intramural Research, National Institute of Allergy and Infectious DiseasesAcademy of FinlandNorwegian Research CouncilStiftelsen Kristian Gerhard JebsenUniversity of BergenSigrid Jusélius FoundationFolkhälsan Research FoundationFoundation for Pediatric Research<h4>Context</h4>Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED; also known as autoimmune polyendocrine syndrome type 1) has a severe, unpredictable course. Autoimmunity and disease components may affect fertility and predispose to maternal and fetal complications, but pregnancy outcomes remain unknown.<h4>Objective</h4>To assess fetal and maternal outcomes and course of clinical APECED manifestations during pregnancy in women with APECED.<h4>Design and setting</h4>A multicenter registry-based study including 5 national patient cohorts.<h4>Patients</h4>321 females with APECED.<h4>Main outcome measure</h4>Number of pregnancies, miscarriages, and deliveries.<h4>Results</h4>Forty-three patients had altogether 83 pregnancies at median age of 27 years (range, 17-39). SixtThe Journal of clinical endocrinology and metabolisme528-e537https://www.ebi.ac.uk/biostudies/studies/S-EPMC8764323biostudies-literaturePregnancy Outcome in Women With APECED (APS-1): A Multicenter Study on 43 Females With 83 Pregnancies.PMC8764323Schmitt MMKareva MHusebye ESVogt EMakitie OBetterle CSabbadin CSaari VOrlova ELionakis MSWiner KKLaakso SHolopainen EfalsePregnancy Outcome in Women With APECED (APS-1): A Multicenter Study on 43 Females With 83 Pregnancies.<h4>Context</h4>Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED; also known as autoimmune polyendocrine syndrome type 1) has a severe, unpredictable course. Autoimmunity and disease components may affect fertility and predispose to maternal and fetal complications, but pregnancy outcomes remain unknown.<h4>Objective</h4>To assess fetal and maternal outcomes and course of clinical APECED manifestations during pregnancy in women with APECED.<h4>Design and setting</h4>A multicenter registry-based study including 5 national patient cohorts.<h4>Patients</h4>321 females with APECED.<h4>Main outcome measure</h4>Number of pregnancies, miscarriages, and deliveries.<h4>Results</h4>Forty-three patients had altogether 83 pregnancies at median age of 27 years (range, 17-39). Sixt2022-01-01T00:00:00Z2022 Jan2025-04-20T03:08:33.543Z2022-02-11T16:12:01.069ZS-EPMC87643233457021510.1210/clinem/dgab705