{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cubria MB"],"funding":["NIAID NIH HHS","HHS | NIH | National Institute of Allergy and Infectious Diseases"],"pagination":["e0071421"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8765267"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["66(1)"],"pubmed_abstract":["Identified in the 1970s as the leading cause of invasive bacterial disease in neonates and young infants, group B Streptococcus (GBS) is now also recognized as a significant cause of morbidity and mortality among adults with underlying medical conditions and the elderly. Concomitant with the increasing incidence of GBS invasive disease in adults is the rise of resistance among GBS isolates to second line antibiotics. Previous research shows that among serotype V GBS, one of the most common capsular types causing adult invasive disease, sequence type 1 (ST1), accounts for an overwhelming majority of adult invasive disease isolates and frequently harbors macrolide resistance. In this study, using whole-genome sequencing data from strains isolated in the United States and Canada over a 45-yea"],"journal":["Antimicrobial agents and chemotherapy"],"pubmed_title":["Population Genomics Reveals Distinct Temporal Association with the Emergence of ST1 Serotype V Group B Streptococcus and Macrolide Resistance in North America."],"pmcid":["PMC8765267"],"funding_grant_id":["AI141349","R21 AI153663","T32 AI141349","AI153663"],"pubmed_authors":["Shropshire WC","Regmi S","Vega LA","Rench M","Sanson MA","Cubria MB","Baker CJ","Shah BJ","Flores AR"],"additional_accession":[]},"is_claimable":false,"name":"Population Genomics Reveals Distinct Temporal Association with the Emergence of ST1 Serotype V Group B Streptococcus and Macrolide Resistance in North America.","description":"Identified in the 1970s as the leading cause of invasive bacterial disease in neonates and young infants, group B Streptococcus (GBS) is now also recognized as a significant cause of morbidity and mortality among adults with underlying medical conditions and the elderly. Concomitant with the increasing incidence of GBS invasive disease in adults is the rise of resistance among GBS isolates to second line antibiotics. Previous research shows that among serotype V GBS, one of the most common capsular types causing adult invasive disease, sequence type 1 (ST1), accounts for an overwhelming majority of adult invasive disease isolates and frequently harbors macrolide resistance. In this study, using whole-genome sequencing data from strains isolated in the United States and Canada over a 45-yea","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2026-06-10T06:23:53.205Z","creation":"2025-04-07T01:53:18.479Z"},"accession":"S-EPMC8765267","cross_references":{"pubmed":["34633844"],"doi":["10.1128/aac.00714-21","10.1128/AAC.00714-21"]}}