biostudies-literatureUnknown12(1)Khedr MA<h4>Background</h4>Hyaline globules (HGs) in the cytoplasm of Kupffer cells (KCs) have been appraised for being a typical feature of autoimmune hepatitis (AIH). This study aimed to determine how useful Kupffer cell hyaline globules (KCHGs) are in diagnosing AIH vs. other causes of pediatric chronic liver diseases (PCLDs).<h4>Materials and methods</h4>This retrospective study recruited 124 children; 58 with AIH, 50 with chronic hepatitis C virus (HCV) infection, and 16 with Wilson's disease (WD). Two pathologists retrieved paraffin blocks of liver biopsies and prepared new cut sections for Periodic acid-Schiff-Diastase (PAS-D) stain. They independently examined liver biopsies before starting treatment. Two pediatricians reviewed medical records for demographic, clinical, laboratory, and serJournal of clinical and experimental hepatology20-28https://www.ebi.ac.uk/biostudies/studies/S-EPMC8766698biostudies-literatureKupffer Cell Hyaline Globules in Children With Autoimmune Hepatitis.PMC8766698Khedr MASalim TASalem MEAdawy NMEhsan NAGhazy RMElharoun ASSultan MMfalseKupffer Cell Hyaline Globules in Children With Autoimmune Hepatitis.<h4>Background</h4>Hyaline globules (HGs) in the cytoplasm of Kupffer cells (KCs) have been appraised for being a typical feature of autoimmune hepatitis (AIH). This study aimed to determine how useful Kupffer cell hyaline globules (KCHGs) are in diagnosing AIH vs. other causes of pediatric chronic liver diseases (PCLDs).<h4>Materials and methods</h4>This retrospective study recruited 124 children; 58 with AIH, 50 with chronic hepatitis C virus (HCV) infection, and 16 with Wilson's disease (WD). Two pathologists retrieved paraffin blocks of liver biopsies and prepared new cut sections for Periodic acid-Schiff-Diastase (PAS-D) stain. They independently examined liver biopsies before starting treatment. Two pediatricians reviewed medical records for demographic, clinical, laboratory, and ser2022-01-01T00:00:00Z2022 Jan-Feb2025-04-21T15:49:56.993Z2025-04-21T15:49:56.993ZS-EPMC87666983506878110.1016/j.jceh.2021.04.013