biostudies-literatureJiayaspathi ANational Institute of Neurological Disorders and StrokeAmerican Heart AssociationNIA NIH HHSNIDDK NIH HHSAmerican Heart Association-American Stroke AssociationNational Heart, Lung, and Blood InstituteNHLBI NIH HHSNational Institute on Deafness and Other Communication DisordersNational Institutes of HealthNational Institute on Aging51-57https://www.ebi.ac.uk/biostudies/studies/S-EPMC8766899biostudies-literatureUnknown165The association of diabetes mellitus (DM), an established risk factor for dementia in the general population, with incident dementia in patients with atrial fibrillation (AF) has not been explored. We performed a cohort study where we identified subjects with incident AF in the Atherosclerosis Risk in Communities cohort (1987 to 2017) and determined their DM status, fasting blood glucose before AF diagnosis and hemoglobin A1c levels using information from the closest previous study visit. Incident dementia was expert adjudicated using information from cognitive assessments, informant interviews and hospitalization surveillance. We calculated hazard ratios (HRs) and 95% confidence intervals (CIs) of incident dementia for each level of exposure using Cox models and adjusting for potential coThe American journal of cardiologyRelation of Diabetes Mellitus to Incident Dementia in Patients With Atrial Fibrillation (from the Atherosclerosis Risk in Communities Study).PMC87668992U01HL0968992U01HL096814R01-HL708252U01HL09691716EIA26410001HHSN268201700004IU01 HL096917HHSN268201700002IU01 HL096902HHSN268201700002CP30AG066511HHSN268201700004CR01 HL070825K24 HL1524402U01HL096902K24 HL148521HHSN268201700003IHHSN268201700005IR01DK089174HHSN268201700001IHHSN268201700005CK24HL148521R01 DK089174U01 HL096814HHSN268201700001CU01 HL096899P30 AG066511HHSN268201700003CU01 HL096812U012U01HL096812Mosley THChen LYSelvin EGottesman RFKnopman DSNorby FLAlonso AJiayaspathi AfalseRelation of Diabetes Mellitus to Incident Dementia in Patients With Atrial Fibrillation (from the Atherosclerosis Risk in Communities Study).The association of diabetes mellitus (DM), an established risk factor for dementia in the general population, with incident dementia in patients with atrial fibrillation (AF) has not been explored. We performed a cohort study where we identified subjects with incident AF in the Atherosclerosis Risk in Communities cohort (1987 to 2017) and determined their DM status, fasting blood glucose before AF diagnosis and hemoglobin A1c levels using information from the closest previous study visit. Incident dementia was expert adjudicated using information from cognitive assessments, informant interviews and hospitalization surveillance. We calculated hazard ratios (HRs) and 95% confidence intervals (CIs) of incident dementia for each level of exposure using Cox models and adjusting for potential co2022-01-01T00:00:00Z2022 Feb2025-04-19T13:28:59.912Z2025-04-19T13:28:59.912ZS-EPMC87668993488707310.1016/j.amjcard.2021.11.005