{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Samra MM"],"funding":["Higher Education Commision, Pakistan"],"pagination":["7105-7122"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8767366"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["47(6)"],"pubmed_abstract":["Drug development on basis of coordination compounds provides versatile structural and functional properties as compared to other organic compounds. In the present study, a new Ca(II) complex of meloxicam was synthesized and characterized by elemental analysis, FT-IR, UV-Vis, <sup>13</sup>C NMR, SEM-EDX, powder XRD and thermal analysis (TGA). The Ca(II) complex was investigated for its in vitro, in vivo biological activities and in silico docking analysis against COX-1 and COX-2. The spectral analysis indicates that the meloxicam acts as a deprotonated bidentate ligand (coordinated to the metal atom through the amide oxygen and the nitrogen atom of the thiazolyl ring) in the complex. SEM-EDX and powder XRD analysis depicted crystalline morphology of Ca(II) complex with a crystalline size of"],"journal":["Arabian journal for science and engineering"],"pubmed_title":["Synthesis, Spectroscopic and Biological Investigation of a New Ca(II) Complex of Meloxicam as Potential COX-2 Inhibitor."],"pmcid":["PMC8767366"],"funding_grant_id":["pin # 518-85878-2PS5-066"],"pubmed_authors":["Sadia A","Samra MM","Imran M","Basra MAR","Ahmad I","Azam M"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis, Spectroscopic and Biological Investigation of a New Ca(II) Complex of Meloxicam as Potential COX-2 Inhibitor.","description":"Drug development on basis of coordination compounds provides versatile structural and functional properties as compared to other organic compounds. In the present study, a new Ca(II) complex of meloxicam was synthesized and characterized by elemental analysis, FT-IR, UV-Vis, <sup>13</sup>C NMR, SEM-EDX, powder XRD and thermal analysis (TGA). The Ca(II) complex was investigated for its in vitro, in vivo biological activities and in silico docking analysis against COX-1 and COX-2. The spectral analysis indicates that the meloxicam acts as a deprotonated bidentate ligand (coordinated to the metal atom through the amide oxygen and the nitrogen atom of the thiazolyl ring) in the complex. SEM-EDX and powder XRD analysis depicted crystalline morphology of Ca(II) complex with a crystalline size of","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-20T03:07:46.888Z","creation":"2022-02-11T16:08:02.642Z"},"accession":"S-EPMC8767366","cross_references":{"pubmed":["35070636"],"doi":["10.1007/s13369-021-06521-7"]}}