biostudies-literatureSamra MMHigher Education Commision, Pakistan7105-7122https://www.ebi.ac.uk/biostudies/studies/S-EPMC8767366biostudies-literatureUnknown47(6)Drug development on basis of coordination compounds provides versatile structural and functional properties as compared to other organic compounds. In the present study, a new Ca(II) complex of meloxicam was synthesized and characterized by elemental analysis, FT-IR, UV-Vis, ¹³C NMR, SEM-EDX, powder XRD and thermal analysis (TGA). The Ca(II) complex was investigated for its in vitro, in vivo biological activities and in silico docking analysis against COX-1 and COX-2. The spectral analysis indicates that the meloxicam acts as a deprotonated bidentate ligand (coordinated to the metal atom through the amide oxygen and the nitrogen atom of the thiazolyl ring) in the complex. SEM-EDX and powder XRD analysis depicted crystalline morphology of Ca(II) complex with a crystalline size ofArabian journal for science and engineeringSynthesis, Spectroscopic and Biological Investigation of a New Ca(II) Complex of Meloxicam as Potential COX-2 Inhibitor.PMC8767366pin # 518-85878-2PS5-066Sadia ASamra MMImran MBasra MARAhmad IAzam MfalseSynthesis, Spectroscopic and Biological Investigation of a New Ca(II) Complex of Meloxicam as Potential COX-2 Inhibitor.Drug development on basis of coordination compounds provides versatile structural and functional properties as compared to other organic compounds. In the present study, a new Ca(II) complex of meloxicam was synthesized and characterized by elemental analysis, FT-IR, UV-Vis, ¹³C NMR, SEM-EDX, powder XRD and thermal analysis (TGA). The Ca(II) complex was investigated for its in vitro, in vivo biological activities and in silico docking analysis against COX-1 and COX-2. The spectral analysis indicates that the meloxicam acts as a deprotonated bidentate ligand (coordinated to the metal atom through the amide oxygen and the nitrogen atom of the thiazolyl ring) in the complex. SEM-EDX and powder XRD analysis depicted crystalline morphology of Ca(II) complex with a crystalline size of2022-01-01T00:00:00Z20222025-04-20T03:07:46.888Z2022-02-11T16:08:02.642ZS-EPMC87673663507063610.1007/s13369-021-06521-7