{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ha K"],"funding":["NHLBI NIH HHS","National Heart, Lung, and Blood Institute","National Natural Science Foundation of China"],"pagination":["2225-2232"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8767556"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(6)"],"pubmed_abstract":["Platelets play a prominent role in multiple diseases, in particular arterial and venous thrombosis and also in atherosclerosis and cancer. To advance the <i>in vivo</i> study of the biological activity of this cell type from a basic experimental focus to a clinical focus, new translatable platelet-specific molecular imaging agents are required. Herein, we report the development of a near-infrared fluorescence probe based upon tirofiban, a clinically approved small-molecule glycoprotein IIb/IIIa inhibitor (GPIIb/IIIa). Through <i>in vitro</i> experiments with human platelets and <i>in vivo</i> ones in a murine model of deep-vein thrombosis, we demonstrate the avidity of the generated probe for activated platelets, with the added benefit of a short blood half-life, thereby enabling rapid <i>"],"journal":["ACS sensors"],"pubmed_title":["<i>In Vivo</i> Platelet Detection Using a Glycoprotein IIb/IIIa-Targeted Near-Infrared Fluorescence Imaging Probe."],"pmcid":["PMC8767556"],"funding_grant_id":["R01HL133153","R01 HL144550","R01HL144550","R01 HL133153","R01HL150538","R01 HL122388","R01 HL150538","R01 HL137913","R01HL137913","R01HL122238","81800431","R01 HL122238"],"pubmed_authors":["Li W","Kawamura Y","Jaffer FA","Mauskapf A","Zheng X","McCarthy JR","Ha K","Orii M","Hilderbrand SA","Kessinger CW"],"additional_accession":[]},"is_claimable":false,"name":"<i>In Vivo</i> Platelet Detection Using a Glycoprotein IIb/IIIa-Targeted Near-Infrared Fluorescence Imaging Probe.","description":"Platelets play a prominent role in multiple diseases, in particular arterial and venous thrombosis and also in atherosclerosis and cancer. To advance the <i>in vivo</i> study of the biological activity of this cell type from a basic experimental focus to a clinical focus, new translatable platelet-specific molecular imaging agents are required. Herein, we report the development of a near-infrared fluorescence probe based upon tirofiban, a clinically approved small-molecule glycoprotein IIb/IIIa inhibitor (GPIIb/IIIa). Through <i>in vitro</i> experiments with human platelets and <i>in vivo</i> ones in a murine model of deep-vein thrombosis, we demonstrate the avidity of the generated probe for activated platelets, with the added benefit of a short blood half-life, thereby enabling rapid <i>","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2025-04-25T22:22:16.996Z","creation":"2025-04-06T09:04:48.094Z"},"accession":"S-EPMC8767556","cross_references":{"pubmed":["34056903"],"doi":["10.1021/acssensors.1c00124"]}}