biostudies-literatureUnknown32(1)Michikawa T<h4>Background</h4>Maternal exposure to fine particulate matter (PM_2.5) was associated with pregnancy complications. However, we still lack comprehensive evidence regarding which specific chemical components of PM_2.5 are more harmful for maternal and foetal health.<h4>Objective</h4>We focused on exposure over the first trimester (0-13 weeks of gestation), which includes the early placentation period, and investigated whether PM_2.5 and its components were associated with placenta-mediated pregnancy complications (combined outcome of small for gestational age, preeclampsia, placental abruption, and stillbirth).<h4>Methods</h4>From 2013 to 2015, we obtained information, from the Japan Perinatal Registry Network database, on 83,454 women who delivered singletonJournal of exposure science & environmental epidemiology135-145https://www.ebi.ac.uk/biostudies/studies/S-EPMC8770113biostudies-literatureExposure to chemical components of fine particulate matter and ozone, and placenta-mediated pregnancy complications in Tokyo: a register-based study.PMC8770113Saito SNitta HMorokuma SYoshino ATakeda YNakahara KMichikawa TKato KNishiwaki YSugata SHoshi JYamazaki STakami AfalseExposure to chemical components of fine particulate matter and ozone, and placenta-mediated pregnancy complications in Tokyo: a register-based study.<h4>Background</h4>Maternal exposure to fine particulate matter (PM_2.5) was associated with pregnancy complications. However, we still lack comprehensive evidence regarding which specific chemical components of PM_2.5 are more harmful for maternal and foetal health.<h4>Objective</h4>We focused on exposure over the first trimester (0-13 weeks of gestation), which includes the early placentation period, and investigated whether PM_2.5 and its components were associated with placenta-mediated pregnancy complications (combined outcome of small for gestational age, preeclampsia, placental abruption, and stillbirth).<h4>Methods</h4>From 2013 to 2015, we obtained information, from the Japan Perinatal Registry Network database, on 83,454 women who delivered singleton2022-01-01T00:00:00Z2022 Jan2025-04-04T21:33:44.452Z2025-04-04T21:33:44.452ZS-EPMC87701133360309710.1038/s41370-021-00299-4