biostudies-literatureHauspurg ANICHD NIH HHSNCATS NIH HHSNHLBI NIH HHS268-276https://www.ebi.ac.uk/biostudies/studies/S-EPMC8771430biostudies-literatureUnknown7(3)<h4>Importance</h4>Hypertensive disorders of pregnancy are associated with future cardiovascular disease, perhaps because of subclinical cardiac dysfunction before pregnancy leading to impaired adaptation to pregnancy. Natriuretic peptides are promising biomarkers for detecting subclinical cardiac dysfunction outside of pregnancy.<h4>Objective</h4>To investigate whether higher concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP) in early pregnancy would be associated with hypertensive disorders of pregnancy and hypertension 2 to 7 years post partum.<h4>Design, setting, and participants</h4>This cohort study used data from the The Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be Heart Health Study, a prospective multicenter observational study. A total of 410JAMA cardiologyAssociation of N-Terminal Pro-Brain Natriuretic Peptide Concentration in Early Pregnancy With Development of Hypertensive Disorders of Pregnancy and Future Hypertension.PMC8771430U10 HL120018UL1 TR000153U10 HL120019U10 HD063020K12 HD043441U10 HD063041U10 HD063048U10 HD063047U10 HD063046UL1 TR001881U01 HL145358U10 HL120034UL1 TR000439UL1 TR001108U10 HL119989U10 HD063053U10 HD063037U10 HL119993U10 HD063036UL1 TR000124U10 HL119991U10 HL119992UL1 TR002548U10 HL119990U10 HD063072U10 HL120006Williams MYetukuri VWilliams CNHunter SZee PCDavis MWinters AMobley DPham VBasner RCIams JPerkins EWapner RPeters MLatimer CMorby VAlexander BVRouse CEForoud TPemberton VLLynch SDaftary ARKoch MABarnes SChung JHHolder TERedline SMarsh DJShepard JSNhan-Chang CLAraujo BMcFadden DWPolito LWing DADeCain MJHameed AFranklin HMcNeil RBPorto MGreenland PSilver RMLevine LDStraub ACGrobman WACatov JMOnativia AParry SSurovec SPeaceman AMSchubert FPPien GDalton WEmery SPLouis JMTorres CHoffman MKCaritis SNBickus MDiVito MMeadows LReddy UMVorwaller KHauspurg ALaposky ANageotte MPSaade GRNICHD nuMoM2b and NHLBI nuMoM2b Heart Health Study NetworksSpeer PDUlanski JWadhwa PDCampbell PHaas DMLudmir JEsplin MSBairey Merz CNMercer BMElovitz MFuchs KFacco FLMcCormick CLChen YIRumney PJPostma JGriggs CSimhan HNParker CBWillinger MfalseAssociation of N-Terminal Pro-Brain Natriuretic Peptide Concentration in Early Pregnancy With Development of Hypertensive Disorders of Pregnancy and Future Hypertension.<h4>Importance</h4>Hypertensive disorders of pregnancy are associated with future cardiovascular disease, perhaps because of subclinical cardiac dysfunction before pregnancy leading to impaired adaptation to pregnancy. Natriuretic peptides are promising biomarkers for detecting subclinical cardiac dysfunction outside of pregnancy.<h4>Objective</h4>To investigate whether higher concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP) in early pregnancy would be associated with hypertensive disorders of pregnancy and hypertension 2 to 7 years post partum.<h4>Design, setting, and participants</h4>This cohort study used data from the The Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be Heart Health Study, a prospective multicenter observational study. A total of 4102022-01-01T00:00:00Z2022 Mar2026-05-08T02:04:23.459Z2024-11-15T20:05:48.929ZS-EPMC87714303504441810.1001/jamacardio.2021.5617