{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mehr JB"],"funding":["NIDA NIH HHS","National Institute on Drug Abuse"],"pagination":["852-855"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8772282"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(11)"],"pubmed_abstract":["Although originally implicated in appetite and sleep/wakefulness, the hypothalamic orexin (hypocretin) system has now been demonstrably linked with motivated behavior. This highly plastic system responds to reward-associated environmental stimuli and becomes pathologically overactive in addicted states. Here, we provide a brief overview of the roles of the orexin system in reward-seeking and addiction, as well as potential therapeutic opportunities for substance use disorders based on normalizing orexin function."],"journal":["Trends in neurosciences"],"pubmed_title":["Orexin (hypocretin) and addiction."],"pmcid":["PMC8772282"],"funding_grant_id":["R00 045765","R00 DA045765"],"pubmed_authors":["James MH","Mehr JB","Bilotti MM"],"additional_accession":[]},"is_claimable":false,"name":"Orexin (hypocretin) and addiction.","description":"Although originally implicated in appetite and sleep/wakefulness, the hypothalamic orexin (hypocretin) system has now been demonstrably linked with motivated behavior. This highly plastic system responds to reward-associated environmental stimuli and becomes pathologically overactive in addicted states. Here, we provide a brief overview of the roles of the orexin system in reward-seeking and addiction, as well as potential therapeutic opportunities for substance use disorders based on normalizing orexin function.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2025-04-04T22:33:49.532Z","creation":"2025-02-19T03:24:04.348Z"},"accession":"S-EPMC8772282","cross_references":{"pubmed":["34642086"],"doi":["10.1016/j.tins.2021.09.002"]}}