{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Berenyiova A"],"funding":["Scientific Grant Agency of the Ministry of Education, Science, Research and Sport of the Slovak Republic","Slovak Research and Development Agency"],"pagination":["38"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8773407"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects host cells through angiotensin-converting enzyme 2 (ACE2). Concurrently, the product of ACE2 action, angiotensin 1-7 (Ang 1-7), binds to Mas receptors within the cardiovascular system and provides protective effects. Therefore, it is crucial to reveal the role of ACE2 inhibition, especially within pre-existing cardiovascular pathologies. In our study, we imitated the action of SARS-CoV-2 in organisms using the low dose of the ACE2 inhibitor MLN-4760 with the aim of investigating to what degree ACE2 inhibition is detrimental to the cardiovascular system of spontaneously hypertensive rats (SHRs), which represent a model of human essential hypertension. Our study revealed the complex action of MLN-4760 in SHRs. On the one ha"],"journal":["Biomedicines"],"pubmed_title":["Vascular Effects of Low-Dose ACE2 Inhibitor MLN-4760-Benefit or Detriment in Essential Hypertension?"],"pmcid":["PMC8773407"],"funding_grant_id":["PP-COVID-20-0043, APVV-20-0421","VEGA 2/0111/19"],"pubmed_authors":["Balis P","Cacanyiova S","Zemancikova A","Golas S","Krskova K","Valaskova Z","Cebova M","Dayar E","Drobna M","Liskova S","Berenyiova A","Bernatova I","Zorad S"],"additional_accession":[]},"is_claimable":false,"name":"Vascular Effects of Low-Dose ACE2 Inhibitor MLN-4760-Benefit or Detriment in Essential Hypertension?","description":"Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects host cells through angiotensin-converting enzyme 2 (ACE2). Concurrently, the product of ACE2 action, angiotensin 1-7 (Ang 1-7), binds to Mas receptors within the cardiovascular system and provides protective effects. Therefore, it is crucial to reveal the role of ACE2 inhibition, especially within pre-existing cardiovascular pathologies. In our study, we imitated the action of SARS-CoV-2 in organisms using the low dose of the ACE2 inhibitor MLN-4760 with the aim of investigating to what degree ACE2 inhibition is detrimental to the cardiovascular system of spontaneously hypertensive rats (SHRs), which represent a model of human essential hypertension. Our study revealed the complex action of MLN-4760 in SHRs. On the one ha","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-05-29T21:12:03.928Z","creation":"2025-05-29T21:12:03.928Z"},"accession":"S-EPMC8773407","cross_references":{"pubmed":["35052717"],"doi":["10.3390/biomedicines10010038"]}}