biostudies-literatureBerenyiova AScientific Grant Agency of the Ministry of Education, Science, Research and Sport of the Slovak RepublicSlovak Research and Development Agency38https://www.ebi.ac.uk/biostudies/studies/S-EPMC8773407biostudies-literatureUnknown10(1)Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects host cells through angiotensin-converting enzyme 2 (ACE2). Concurrently, the product of ACE2 action, angiotensin 1-7 (Ang 1-7), binds to Mas receptors within the cardiovascular system and provides protective effects. Therefore, it is crucial to reveal the role of ACE2 inhibition, especially within pre-existing cardiovascular pathologies. In our study, we imitated the action of SARS-CoV-2 in organisms using the low dose of the ACE2 inhibitor MLN-4760 with the aim of investigating to what degree ACE2 inhibition is detrimental to the cardiovascular system of spontaneously hypertensive rats (SHRs), which represent a model of human essential hypertension. Our study revealed the complex action of MLN-4760 in SHRs. On the one haBiomedicinesVascular Effects of Low-Dose ACE2 Inhibitor MLN-4760-Benefit or Detriment in Essential Hypertension?PMC8773407PP-COVID-20-0043, APVV-20-0421VEGA 2/0111/19Balis PCacanyiova SZemancikova AGolas SKrskova KValaskova ZCebova MDayar EDrobna MLiskova SBerenyiova ABernatova IZorad SfalseVascular Effects of Low-Dose ACE2 Inhibitor MLN-4760-Benefit or Detriment in Essential Hypertension?Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects host cells through angiotensin-converting enzyme 2 (ACE2). Concurrently, the product of ACE2 action, angiotensin 1-7 (Ang 1-7), binds to Mas receptors within the cardiovascular system and provides protective effects. Therefore, it is crucial to reveal the role of ACE2 inhibition, especially within pre-existing cardiovascular pathologies. In our study, we imitated the action of SARS-CoV-2 in organisms using the low dose of the ACE2 inhibitor MLN-4760 with the aim of investigating to what degree ACE2 inhibition is detrimental to the cardiovascular system of spontaneously hypertensive rats (SHRs), which represent a model of human essential hypertension. Our study revealed the complex action of MLN-4760 in SHRs. On the one ha2021-01-01T00:00:00Z2021 Dec2025-05-29T21:12:03.928Z2025-05-29T21:12:03.928ZS-EPMC87734073505271710.3390/biomedicines10010038