{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nunes MC"],"funding":["Department of Science and Technology and National Research Foundation","Bill and Melinda Gates Foundation","South African Medical Research Council"],"pagination":["e0262179"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8775212"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["Comparisons of histopathological features and microbiological findings between decedents with respiratory symptoms due to SARS-CoV-2 infection or other causes, in settings with high prevalence of HIV and Mycobacterium tuberculosis (MTB) infections have not been reported. Deaths associated with a positive ante-mortem SARS-CoV-2 PCR test and/or respiratory disease symptoms at Chris Hani Baragwanath Academic Hospital in Soweto, South Africa from 15th April to 2nd November 2020, during the first wave of the South African COVID-19 epidemic, were investigated. Deceased adult patients had post-mortem minimally-invasive tissue sampling (MITS) performed to investigate for SARS-CoV-2 infection and molecular detection of putative pathogens on blood and lung samples, and histopathology examination of "],"journal":["PloS one"],"pubmed_title":["Clinical characteristics and histopathology of COVID-19 related deaths in South African adults."],"pmcid":["PMC8775212"],"funding_grant_id":["South African Research Chair Initiative in Vaccine Preventable Diseases","INV-016202","SHIP NCD 96756"],"pubmed_authors":["Thwala BN","Dludlu N","Menezes C","Laubscher M","Mahtab S","Baillie VL","Nunes MC","Hale MJ","Mabena FC","Mckenzie S","van Blydenstein S","Dulisse B","Madhi SA","Serafin N","Tsitsi M","du Plessis J","Mtshali S","Els T"],"additional_accession":[]},"is_claimable":false,"name":"Clinical characteristics and histopathology of COVID-19 related deaths in South African adults.","description":"Comparisons of histopathological features and microbiological findings between decedents with respiratory symptoms due to SARS-CoV-2 infection or other causes, in settings with high prevalence of HIV and Mycobacterium tuberculosis (MTB) infections have not been reported. Deaths associated with a positive ante-mortem SARS-CoV-2 PCR test and/or respiratory disease symptoms at Chris Hani Baragwanath Academic Hospital in Soweto, South Africa from 15th April to 2nd November 2020, during the first wave of the South African COVID-19 epidemic, were investigated. Deceased adult patients had post-mortem minimally-invasive tissue sampling (MITS) performed to investigate for SARS-CoV-2 infection and molecular detection of putative pathogens on blood and lung samples, and histopathology examination of ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-06-04T03:22:59.361Z","creation":"2025-05-18T12:09:32.287Z"},"accession":"S-EPMC8775212","cross_references":{"pubmed":["35051205"],"doi":["10.1371/journal.pone.0262179"]}}