biostudies-literatureCao TNIBIB NIH HHSNHLBI NIH HHSNIAMS NIH HHS1375-1389https://www.ebi.ac.uk/biostudies/studies/S-EPMC8776611biostudies-literatureUnknown87(3)<h4>Purpose</h4>To develop a new technique that enables simultaneous quantification of whole-brain T₁ , T₂ , T2∗ , as well as susceptibility and synthesis of six contrast-weighted images in a single 9.1-minute scan.<h4>Methods</h4>The technique uses hybrid T₂ -prepared inversion-recovery pulse modules and multi-echo gradient-echo readouts to collect k-space data with various T1, T2, and T2∗ weightings. The underlying image is represented as a six-dimensional low-rank tensor consisting of three spatial dimensions and three temporal dimensions corresponding to T₁ recovery, T₂ decay, and multi-echo behaviors, respectively. Multiparametric maps were fitted from reconstructed image series. The proposed method was validated on phantoms and hMagnetic resonance in medicineThree-dimensional simultaneous brain mapping of T1, T2, T2∗ and magnetic susceptibility with MR Multitasking.PMC8776611R01 AR066517R01 EB028146R01 HL156818Christodoulou AGMa SXie YFan ZHogg ELi DWu CWang NTagliati MCao TGharabaghi SHaacke EMHan FfalseThree-dimensional simultaneous brain mapping of T1, T2, T2∗ and magnetic susceptibility with MR Multitasking.<h4>Purpose</h4>To develop a new technique that enables simultaneous quantification of whole-brain T₁ , T₂ , T2∗ , as well as susceptibility and synthesis of six contrast-weighted images in a single 9.1-minute scan.<h4>Methods</h4>The technique uses hybrid T₂ -prepared inversion-recovery pulse modules and multi-echo gradient-echo readouts to collect k-space data with various T1, T2, and T2∗ weightings. The underlying image is represented as a six-dimensional low-rank tensor consisting of three spatial dimensions and three temporal dimensions corresponding to T₁ recovery, T₂ decay, and multi-echo behaviors, respectively. Multiparametric maps were fitted from reconstructed image series. The proposed method was validated on phantoms and h2022-01-01T00:00:00Z2022 Mar2025-04-04T21:43:46.156Z2025-04-04T21:43:46.156ZS-EPMC87766113470843810.1002/mrm.29059