{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Garelja ML"],"funding":["National Institute of Neurological Disorders and Stroke","Maurice Wilkins Centre for Molecular Biodiscovery","NINDS NIH HHS","Health Research Council of New Zealand"],"pagination":["416-434"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8776895"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["179(3)"],"pubmed_abstract":["<h4>Background and purpose</h4>The calcitonin (CT) receptor family is complex, comprising two receptors (the CT receptor [CTR] and the CTR-like receptor [CLR]), three accessory proteins (RAMPs) and multiple endogenous peptides. This family contains several important drug targets, including CGRP, which is targeted by migraine therapeutics. The pharmacology of this receptor family is poorly characterised in species other than rats and humans. To facilitate understanding of translational and preclinical data, we need to know the receptor pharmacology of this family in mice.<h4>Experimental approach</h4>Plasmids encoding mouse CLR/CTR and RAMPs were transiently transfected into Cos-7 cells. cAMP production was measured in response to agonists in the absence or presence of antagonists.<h4>Key r"],"journal":["British journal of pharmacology"],"pubmed_title":["Pharmacological characterisation of mouse calcitonin and calcitonin receptor-like receptors reveals differences compared with human receptors."],"pmcid":["PMC8776895"],"funding_grant_id":["RF1 NS113839","NS113839"],"pubmed_authors":["Siow A","Jamaluddin MA","Hay DL","Walker CS","Bower RL","Chand S","Petersen J","Brimble MA","Garelja ML","Harris PWR"],"additional_accession":[]},"is_claimable":false,"name":"Pharmacological characterisation of mouse calcitonin and calcitonin receptor-like receptors reveals differences compared with human receptors.","description":"<h4>Background and purpose</h4>The calcitonin (CT) receptor family is complex, comprising two receptors (the CT receptor [CTR] and the CTR-like receptor [CLR]), three accessory proteins (RAMPs) and multiple endogenous peptides. This family contains several important drug targets, including CGRP, which is targeted by migraine therapeutics. The pharmacology of this receptor family is poorly characterised in species other than rats and humans. To facilitate understanding of translational and preclinical data, we need to know the receptor pharmacology of this family in mice.<h4>Experimental approach</h4>Plasmids encoding mouse CLR/CTR and RAMPs were transiently transfected into Cos-7 cells. cAMP production was measured in response to agonists in the absence or presence of antagonists.<h4>Key r","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2026-05-08T02:11:43.546Z","creation":"2024-11-20T07:42:38.388Z"},"accession":"S-EPMC8776895","cross_references":{"pubmed":["34289083"],"doi":["10.1111/bph.15628"]}}