{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schoenfeld AJ"],"funding":["NIAMS NIH HHS"],"pagination":["2221-2228"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8776911"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["103(23)"],"pubmed_abstract":["<h4>Background</h4>Operative and nonoperative treatments for spinal metastases are expensive interventions with a high rate of complications. We sought to determine the cost-effectiveness of a surgical procedure compared with nonoperative management as treatment for spinal metastases.<h4>Methods</h4>We constructed a Markov state-transition model with health states defined by ambulatory status and estimated the quality-adjusted life-years (QALYs) and costs for operative and nonoperative management of spine metastases. We considered 2 populations: 1 in which patients presented with independent ambulatory status and 1 in which patients presented with nonambulatory status due to acute (e.g., <48 hours) metastatic epidural compression. We defined the efficacy of each treatment as a likelihood o"],"journal":["The Journal of bone and joint surgery. American volume"],"pubmed_title":["The Cost-Effectiveness of Surgical Intervention for Spinal Metastases: A Model-Based Evaluation."],"pmcid":["PMC8776911"],"funding_grant_id":["P30 AR072577","K24 AR057827","K23 AR071464"],"pubmed_authors":["Losina E","Schoenfeld AJ","Blucher JA","Katz JN","Harris MB","Bensen GP","Ferrone ML","Balboni TA","Schwab JH"],"additional_accession":[]},"is_claimable":false,"name":"The Cost-Effectiveness of Surgical Intervention for Spinal Metastases: A Model-Based Evaluation.","description":"<h4>Background</h4>Operative and nonoperative treatments for spinal metastases are expensive interventions with a high rate of complications. We sought to determine the cost-effectiveness of a surgical procedure compared with nonoperative management as treatment for spinal metastases.<h4>Methods</h4>We constructed a Markov state-transition model with health states defined by ambulatory status and estimated the quality-adjusted life-years (QALYs) and costs for operative and nonoperative management of spine metastases. We considered 2 populations: 1 in which patients presented with independent ambulatory status and 1 in which patients presented with nonambulatory status due to acute (e.g., <48 hours) metastatic epidural compression. We defined the efficacy of each treatment as a likelihood o","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2026-04-17T17:20:24.542Z","creation":"2025-04-04T08:58:31.688Z"},"accession":"S-EPMC8776911","cross_references":{"pubmed":["34288901"],"doi":["10.2106/JBJS.21.00023","10.2106/jbjs.21.00023"]}}