{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Korzets Y"],"pubmed_abstract":["<h4>Background</h4>Menstrual and parity history might impact the risk for breast cancer. Data on the impact of these factors on other tumor characteristics are limited.<h4>Methods</h4>A single center retrospective cohort study comprising all women with estrogen receptor (ER) positive, human epidermal growth factor receptor 2 (HER2) negative, early breast cancer whose tumors were sent to OncotypeDX analysis. The prespecified subgroups were investigated: age of menarche (< 12 vs. ≥ 12 years), number of deliveries (0 vs. ≥ 1 childbirth and ≥ 5 childbirth vs. other), age of first delivery (≥ 30 years vs. younger age) and postmenopausal compared to premenopausal. The impact of age of menopause was also assessed categorically, using early (< 45 years) and late age of menopause (> 55 years). Diff"],"journal":["Discover. Oncology"],"pagination":["26"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8777527"],"repository":["biostudies-literature"],"pubmed_title":["The impact of endogenous estrogen exposures on the characteristics and outcomes of estrogen receptor positive, early breast cancer."],"pmcid":["PMC8777527"],"pubmed_authors":["Mutai R","Shochat T","Moore A","Korzets Y","Yariv O","Goldvaser H","Yerushalmi R"],"additional_accession":[]},"is_claimable":false,"name":"The impact of endogenous estrogen exposures on the characteristics and outcomes of estrogen receptor positive, early breast cancer.","description":"<h4>Background</h4>Menstrual and parity history might impact the risk for breast cancer. Data on the impact of these factors on other tumor characteristics are limited.<h4>Methods</h4>A single center retrospective cohort study comprising all women with estrogen receptor (ER) positive, human epidermal growth factor receptor 2 (HER2) negative, early breast cancer whose tumors were sent to OncotypeDX analysis. The prespecified subgroups were investigated: age of menarche (< 12 vs. ≥ 12 years), number of deliveries (0 vs. ≥ 1 childbirth and ≥ 5 childbirth vs. other), age of first delivery (≥ 30 years vs. younger age) and postmenopausal compared to premenopausal. The impact of age of menopause was also assessed categorically, using early (< 45 years) and late age of menopause (> 55 years). Diff","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-18T17:08:54.301Z","creation":"2025-04-07T04:44:02.083Z"},"accession":"S-EPMC8777527","cross_references":{"pubmed":["35201434"],"doi":["10.1007/s12672-021-00420-x"]}}