{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yan JX"],"funding":["Swiss National Science Foundation","NIAID NIH HHS","National Institute of Health","United States Department of Agriculture","University of Wisconsin-Madison","National Institutes of Health","NIH HHS","National Science Foundation"],"pagination":["43"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8779896"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["Chemical investigations of a marine sponge-associated <i>Bacillus</i> revealed six new imidazolium-containing compounds, bacillimidazoles A-F (<b>1</b>-<b>6</b>). Previous reports of related imidazolium-containing natural products are rare. Initially unveiled by timsTOF (trapped ion mobility spectrometry) MS data, extensive HRMS and 1D and 2D NMR analyses enabled the structural elucidation of <b>1</b>-<b>6</b>. In addition, a plausible biosynthetic pathway to bacillimidazoles is proposed based on isotopic labeling experiments and invokes the highly reactive glycolytic adduct 2,3-butanedione. Combined, the results of structure elucidation efforts, isotopic labeling studies and bioinformatics suggest that <b>1</b>-<b>6</b> result from a fascinating intersection of primary and secondary metab"],"journal":["Marine drugs"],"pubmed_title":["Bacillimidazoles A-F, Imidazolium-Containing Compounds Isolated from a Marine <i>Bacillus</i>."],"pmcid":["PMC8779896"],"funding_grant_id":["multiple funds through School of Pharmacy & the Graduate School","multiple funds through School of Pharmacy &amp; the Graduate School","RR02781","Postdoctoral Mobility Fellowship","OIA-9977484","unknown","U19AI141720","DMB-8415048","U19AI109673","BIR-9214394","U19 AI109673","RR08438","P41GM103399","R01AT009874","U19 AI142720"],"pubmed_authors":["Yan JX","Ananiev GE","Helfrich EJN","Clardy J","Chevrette MG","Heyman H","Wu Q","Currie CR","Bugni TS","Braun DR","Rajski SR"],"additional_accession":[]},"is_claimable":false,"name":"Bacillimidazoles A-F, Imidazolium-Containing Compounds Isolated from a Marine <i>Bacillus</i>.","description":"Chemical investigations of a marine sponge-associated <i>Bacillus</i> revealed six new imidazolium-containing compounds, bacillimidazoles A-F (<b>1</b>-<b>6</b>). Previous reports of related imidazolium-containing natural products are rare. Initially unveiled by timsTOF (trapped ion mobility spectrometry) MS data, extensive HRMS and 1D and 2D NMR analyses enabled the structural elucidation of <b>1</b>-<b>6</b>. In addition, a plausible biosynthetic pathway to bacillimidazoles is proposed based on isotopic labeling experiments and invokes the highly reactive glycolytic adduct 2,3-butanedione. Combined, the results of structure elucidation efforts, isotopic labeling studies and bioinformatics suggest that <b>1</b>-<b>6</b> result from a fascinating intersection of primary and secondary metab","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2026-05-02T03:12:43.672Z","creation":"2022-02-11T16:19:08.665Z"},"accession":"S-EPMC8779896","cross_references":{"pubmed":["35049898"],"doi":["10.3390/md20010043"]}}