biostudies-literatureLeung AKLNIAID NIH HHSNational Institutes of HealthNIGMS NIH HHSNIH HHS94https://www.ebi.ac.uk/biostudies/studies/S-EPMC8780475biostudies-literatureUnknown11(1)Emerging and re-emerging viral diseases pose continuous public health threats, and effective control requires a combination of non-pharmacologic interventions, treatment with antivirals, and prevention with vaccines. The COVID-19 pandemic has demonstrated that the world was least prepared to provide effective treatments. This lack of preparedness has been due, in large part, to a lack of investment in developing a diverse portfolio of antiviral agents, particularly those ready to combat viruses of pandemic potential. Here, we focus on a drug target called macrodomain that is critical for the replication and pathogenesis of alphaviruses and coronaviruses. Some mutations in alphavirus and coronaviral macrodomains are not tolerated for virus replication. In addition, the coronavirus macrodomaPathogens (Basel, Switzerland)The Conserved Macrodomain Is a Potential Therapeutic Target for Coronaviruses and Alphaviruses.PMC8780475R35 GM138029R01 GM104135R56 AI137264K22AI134933R56AI137264R01GM104135R35GM138029Fehr ARLeung AKLGriffin DEBosch JfalseThe Conserved Macrodomain Is a Potential Therapeutic Target for Coronaviruses and Alphaviruses.Emerging and re-emerging viral diseases pose continuous public health threats, and effective control requires a combination of non-pharmacologic interventions, treatment with antivirals, and prevention with vaccines. The COVID-19 pandemic has demonstrated that the world was least prepared to provide effective treatments. This lack of preparedness has been due, in large part, to a lack of investment in developing a diverse portfolio of antiviral agents, particularly those ready to combat viruses of pandemic potential. Here, we focus on a drug target called macrodomain that is critical for the replication and pathogenesis of alphaviruses and coronaviruses. Some mutations in alphavirus and coronaviral macrodomains are not tolerated for virus replication. In addition, the coronavirus macrodoma2022-01-01T00:00:00Z2022 Jan2025-04-21T17:36:55.39Z2022-02-11T15:51:06.944ZS-EPMC87804753505604210.3390/pathogens11010094