{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["O'Dell CT"],"funding":["University of Rochester","NIAID NIH HHS","NIEHS NIH HHS","NHLBI NIH HHS","National Institutes of Health","University of Rochester Provost’s Research Award"],"pagination":["105-117"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8782265"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["The prevalence of unconventional oil and gas (UOG) operations raises concerns regarding the potential for adverse health outcomes following exposure to water tainted by mixtures of UOG associated chemicals. The potential effects that exposure to complex chemical mixtures has on the immune system have yet to be fully evaluated. In this study, effects on the immune system of adult mice exposed to a mixture of 23 chemicals that have been associated with water near active UOG operations were investigated. Female and male mice were exposed to the mixture <i>via</i> their drinking water for at least 8 weeks. At the end of the exposure, cellularity of primary and secondary immune organs, as well as an immune system function, were assessed using three different models of disease, i.e. house dust m"],"journal":["Journal of immunotoxicology"],"pubmed_title":["Exposure to a mixture of 23 chemicals associated with unconventional oil and gas operations alters immune response to challenge in adult mice."],"pmcid":["PMC8782265"],"funding_grant_id":["T32 ES007026","R01 AI073772","R01ES030300","P30 ES001247","R01 ES030300","R21ES030690","R01 ES023260","R21 ES030690","T32 HL066988","T32HL066988","R01ES23260","P30ES001247","T32ES007026","R24 AI059830","R01 ES004862","R01AI073772","R24AI059830"],"pubmed_authors":["Georas SN","O'Dell CT","Lawrence BP","Boule LA","Eliseeva S","Robert J"],"additional_accession":[]},"is_claimable":false,"name":"Exposure to a mixture of 23 chemicals associated with unconventional oil and gas operations alters immune response to challenge in adult mice.","description":"The prevalence of unconventional oil and gas (UOG) operations raises concerns regarding the potential for adverse health outcomes following exposure to water tainted by mixtures of UOG associated chemicals. The potential effects that exposure to complex chemical mixtures has on the immune system have yet to be fully evaluated. In this study, effects on the immune system of adult mice exposed to a mixture of 23 chemicals that have been associated with water near active UOG operations were investigated. Female and male mice were exposed to the mixture <i>via</i> their drinking water for at least 8 weeks. At the end of the exposure, cellularity of primary and secondary immune organs, as well as an immune system function, were assessed using three different models of disease, i.e. house dust m","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-26T09:48:35.98Z","creation":"2025-04-06T13:06:27.104Z"},"accession":"S-EPMC8782265","cross_references":{"pubmed":["34455897"],"doi":["10.1080/1547691x.2021.1965677","10.1080/1547691X.2021.1965677"]}}