biostudies-literatureRezk-Hanna MUCLA Academic Publishing ServicesNCATS NIH HHSNIDA NIH HHSNHLBI NIH HHSNational Heart, Lung, and Blood InstituteClinical and Translational Science Institute, University of California, Los AngelesNIHNational Institute on Drug Abuse208-218https://www.ebi.ac.uk/biostudies/studies/S-EPMC8783031biostudies-literatureUnknown161(1)<h4>Background</h4>Traditional hookah smoking has grown quickly to become a global tobacco epidemic. More recently, electronic hookahs (e-hookahs)-vaped through traditional water pipes-were introduced as healthier alternatives to combustible hookah. With combustible tobacco smoking, oxidative stress, inflammation, and vascular stiffness are key components in the development and progression of atherosclerosis. The comparable effects of hookah are unknown.<h4>Research question</h4>What is the differential acute effect of e-hookah vaping vs combustible hookah smoking on oxidation, inflammation, and arterial stiffness?<h4>Study design and methods</h4>In a randomized crossover design study, among a cohort of 17 healthy young adult chronic hookah smokers, we investigated the effect of e-hookah vChestDifferential Effects of Electronic Hookah Vaping and Traditional Combustible Hookah Smoking on Oxidation, Inflammation, and Arterial Stiffness.PMC8783031UL1TR000124P30 DA012393UL1 TR000124R21 HL1450021R21HL145002-01P30 DA12393Gupta RDobrin DRezk-Hanna MCheng CWNettle COTashkin DPBrecht MLMeans AAraujo JAfalseDifferential Effects of Electronic Hookah Vaping and Traditional Combustible Hookah Smoking on Oxidation, Inflammation, and Arterial Stiffness.<h4>Background</h4>Traditional hookah smoking has grown quickly to become a global tobacco epidemic. More recently, electronic hookahs (e-hookahs)-vaped through traditional water pipes-were introduced as healthier alternatives to combustible hookah. With combustible tobacco smoking, oxidative stress, inflammation, and vascular stiffness are key components in the development and progression of atherosclerosis. The comparable effects of hookah are unknown.<h4>Research question</h4>What is the differential acute effect of e-hookah vaping vs combustible hookah smoking on oxidation, inflammation, and arterial stiffness?<h4>Study design and methods</h4>In a randomized crossover design study, among a cohort of 17 healthy young adult chronic hookah smokers, we investigated the effect of e-hookah v2022-01-01T00:00:00Z2022 Jan2025-04-05T07:13:17.588Z2022-02-11T15:37:42.517ZS-EPMC87830313429800710.1016/j.chest.2021.07.027