biostudies-literatureThombre Kulkarni MNHLBI NIH HHSNCI NIH HHSe2144391https://www.ebi.ac.uk/biostudies/studies/S-EPMC8783263biostudies-literatureUnknown5(1)<h4>Importance</h4>Early natural menopause (ENM) has been associated with reduced reproductive span, cardiovascular disease risk, and early mortality. The potential adverse implications of endometrioma surgery for ovarian reserve are known, yet the association of endometriosis with menopausal timing remains understudied.<h4>Objective</h4>To investigate the association between endometriosis and risk for ENM.<h4>Design, setting, and participants</h4>This large, population-based cohort study analyzed data from the Nurses' Health Study II cohort questionnaires from the 1989 to 2015 questionnaire cycles. The sample included premenopausal women aged 25 to 42 years at baseline or enrollment in 1989. Cumulative follow-up rate was greater than 90%, and participants continued follow-up until the onsJAMA network openAssociation Between Laparoscopically Confirmed Endometriosis and Risk of Early Natural Menopause.PMC8783263U01 HL145386U01 CA176726Whitcomb BWEliassen AHMissmer SAThombre Kulkarni MFarland LVTerry KLShafrir ABertone-Johnson ERfalseAssociation Between Laparoscopically Confirmed Endometriosis and Risk of Early Natural Menopause.<h4>Importance</h4>Early natural menopause (ENM) has been associated with reduced reproductive span, cardiovascular disease risk, and early mortality. The potential adverse implications of endometrioma surgery for ovarian reserve are known, yet the association of endometriosis with menopausal timing remains understudied.<h4>Objective</h4>To investigate the association between endometriosis and risk for ENM.<h4>Design, setting, and participants</h4>This large, population-based cohort study analyzed data from the Nurses' Health Study II cohort questionnaires from the 1989 to 2015 questionnaire cycles. The sample included premenopausal women aged 25 to 42 years at baseline or enrollment in 1989. Cumulative follow-up rate was greater than 90%, and participants continued follow-up until the ons2022-01-01T00:00:00Z2022 Jan2025-04-25T17:12:52.979Z2025-04-06T04:03:01.419ZS-EPMC87832633506103910.1001/jamanetworkopen.2021.44391