{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Antiguas A"],"funding":["NCI NIH HHS","National Institutes of Health","NIAMS NIH HHS","NIGMS NIH HHS"],"pagination":["314-322"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8784568"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["142(2)"],"pubmed_abstract":["IRF6 is a transcription factor that is required for craniofacial development and epidermal morphogenesis. Specifically, Irf6-deficient mice lack the terminally differentiated epidermal layers, leading to an absence of barrier function. This phenotype also includes intraoral adhesions due to the absence of the oral periderm, leading to the mislocalization of E-cadherin and other cell‒cell adhesion proteins of the oral epithelium. However, the mechanisms by which IRF6 controls the localization of cell adhesion proteins are not understood. In this study, we show that in human and murine keratinocytes, loss of IRF6 leads to a breakdown of epidermal sheets after mechanical stress. This defect is due to a reduction of adhesion proteins at the plasma membrane. Dynamin inhibitors rescued the IRF6-"],"journal":["The Journal of investigative dermatology"],"pubmed_title":["IRF6 Regulates the Delivery of E-Cadherin to the Plasma Membrane."],"pmcid":["PMC8784568"],"funding_grant_id":["R01 AR067739","F31 AR078659","R01AR067739","P30 CA086862","R35GM136291","R35 GM136291"],"pubmed_authors":["Dunnwald M","Antiguas A","DeMali KA"],"additional_accession":[]},"is_claimable":false,"name":"IRF6 Regulates the Delivery of E-Cadherin to the Plasma Membrane.","description":"IRF6 is a transcription factor that is required for craniofacial development and epidermal morphogenesis. Specifically, Irf6-deficient mice lack the terminally differentiated epidermal layers, leading to an absence of barrier function. This phenotype also includes intraoral adhesions due to the absence of the oral periderm, leading to the mislocalization of E-cadherin and other cell‒cell adhesion proteins of the oral epithelium. However, the mechanisms by which IRF6 controls the localization of cell adhesion proteins are not understood. In this study, we show that in human and murine keratinocytes, loss of IRF6 leads to a breakdown of epidermal sheets after mechanical stress. This defect is due to a reduction of adhesion proteins at the plasma membrane. Dynamin inhibitors rescued the IRF6-","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-05T09:03:15.06Z","creation":"2025-04-05T09:03:15.06Z"},"accession":"S-EPMC8784568","cross_references":{"pubmed":["34310950"],"doi":["10.1016/j.jid.2021.06.031"]}}