{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tarke A"],"funding":["NIAID NIH HHS","NIH"],"pagination":["847-859.e11"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8784649"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["185(5)"],"pubmed_abstract":["We address whether T cell responses induced by different vaccine platforms (mRNA-1273, BNT162b2, Ad26.COV2.S, and NVX-CoV2373) cross-recognize early SARS-CoV-2 variants. T cell responses to early variants were preserved across vaccine platforms. By contrast, significant overall decreases were observed for memory B cells and neutralizing antibodies. In subjects ∼6 months post-vaccination, 90% (CD4<sup>+</sup>) and 87% (CD8<sup>+</sup>) of memory T cell responses were preserved against variants on average by AIM assay, and 84% (CD4<sup>+</sup>) and 85% (CD8<sup>+</sup>) preserved against Omicron. Omicron RBD memory B cell recognition was substantially reduced to 42% compared with other variants. T cell epitope repertoire analysis revealed a median of 11 and 10 spike epitopes recognized by CD4<sup>+</sup> and CD8<sup>+</sup> T cells, with average preservation > 80% for Omicron. Functional preservation of the majority of T cell responses may play an important role as a second-level defense against diverse variants."],"journal":["Cell"],"pubmed_title":["SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron."],"pmcid":["PMC8784649"],"funding_grant_id":["R01 AI135193","75N93021C00016","P30 AI110527","R25 AI147376","U19 AI142742","75N93019C00065"],"pubmed_authors":["Dan JM","Sette A","Phillips E","Tarke A","Sidney J","Grifoni A","Methot N","Goodwin B","Weiskopf D","Coelho CH","Mallal S","Filaci G","Crotty S","Zhang Z","da Silva Antunes R","Yu ED","Bloom NI"],"additional_accession":[]},"is_claimable":false,"name":"SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron.","description":"We address whether T cell responses induced by different vaccine platforms (mRNA-1273, BNT162b2, Ad26.COV2.S, and NVX-CoV2373) cross-recognize early SARS-CoV-2 variants. T cell responses to early variants were preserved across vaccine platforms. By contrast, significant overall decreases were observed for memory B cells and neutralizing antibodies. In subjects ∼6 months post-vaccination, 90% (CD4<sup>+</sup>) and 87% (CD8<sup>+</sup>) of memory T cell responses were preserved against variants on average by AIM assay, and 84% (CD4<sup>+</sup>) and 85% (CD8<sup>+</sup>) preserved against Omicron. Omicron RBD memory B cell recognition was substantially reduced to 42% compared with other variants. T cell epitope repertoire analysis revealed a median of 11 and 10 spike epitopes recognized by CD4<sup>+</sup> and CD8<sup>+</sup> T cells, with average preservation > 80% for Omicron. Functional preservation of the majority of T cell responses may play an important role as a second-level defense against diverse variants.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-05-31T01:01:00.101Z","creation":"2025-04-04T23:29:35.285Z"},"accession":"S-EPMC8784649","cross_references":{"pubmed":["35139340"],"doi":["10.1016/j.cell.2022.01.015"]}}