{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu T"],"funding":["National Natural Science Foundation of China","Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission"],"pagination":["806465"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8787122"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["<i>Cryptococcus neoformans</i> is an opportunistic yeast-like pathogen that mainly infects immunocompromised individuals and causes fatal meningitis. Sexual reproduction can promote the exchange of genetic material between different strains of <i>C. neoformans</i>, which is one of the reasons leading to the emergence of highly pathogenic and drug-resistant strains of <i>C. neoformans</i>. Although much research has been done on the regulation mechanism of <i>Cryptococcus</i> sexual reproduction, there are few studies on the sexual reproduction regulation of <i>Cryptococcus</i> by the ubiquitin-proteasome system. This study identified an F-box protein, Cdc4, which contains a putative F-box domain and eight WD40 domains. The expression pattern analysis showed that the <i>CDC4</i> gene was ex"],"journal":["Frontiers in cellular and infection microbiology"],"pubmed_title":["Role of F-box Protein Cdc4 in Fungal Virulence and Sexual Reproduction of <i>Cryptococcus neoformans</i>."],"pmcid":["PMC8787122"],"funding_grant_id":["cstc2021jcyj-msxmX1077","31970145; 32170203"],"pubmed_authors":["Guo YB","Han LT","Fan CL","Wu T","Liu TB"],"additional_accession":[]},"is_claimable":false,"name":"Role of F-box Protein Cdc4 in Fungal Virulence and Sexual Reproduction of <i>Cryptococcus neoformans</i>.","description":"<i>Cryptococcus neoformans</i> is an opportunistic yeast-like pathogen that mainly infects immunocompromised individuals and causes fatal meningitis. Sexual reproduction can promote the exchange of genetic material between different strains of <i>C. neoformans</i>, which is one of the reasons leading to the emergence of highly pathogenic and drug-resistant strains of <i>C. neoformans</i>. Although much research has been done on the regulation mechanism of <i>Cryptococcus</i> sexual reproduction, there are few studies on the sexual reproduction regulation of <i>Cryptococcus</i> by the ubiquitin-proteasome system. This study identified an F-box protein, Cdc4, which contains a putative F-box domain and eight WD40 domains. The expression pattern analysis showed that the <i>CDC4</i> gene was ex","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-25T17:11:20.783Z","creation":"2022-02-11T16:00:54.378Z"},"accession":"S-EPMC8787122","cross_references":{"pubmed":["35087766"],"doi":["10.3389/fcimb.2021.806465"]}}