biostudies-literatureKhachatoorian CNIEHS NIH HHS131494https://www.ebi.ac.uk/biostudies/studies/S-EPMC8787941biostudies-literatureUnknown286(Pt 3)<h4>Background</h4>Given the high concentrations of nicotine and flavor chemicals in EC (electronic cigarette) fluids, it is important to determine how efficiently they transfer to aerosols, how well they are retained by users (exposure), and if they are exhaled into the environment where they settle of surfaces forming ECEAR (EC exhaled aerosol residue).<h4>Objectives</h4>To quantify the flavor chemicals and nicotine in refill fluids, inhaled aerosols, and exhaled aerosols. Then deduce their retention and contribution to ECEAR.<h4>Methods</h4>Flavor chemicals and nicotine were identified and quantified by GC-MS in two refill fluids, smoking machine-generated aerosols, and aerosols exhaled by 10 human participants (average age 21; 7 males). Machine generated aerosols were made with varyingChemosphereTracing the movement of electronic cigarette flavor chemicals and nicotine from refill fluids to aerosol, lungs, exhale, and the environment.PMC8787941R01 ES029741McWhirter KJLuo WTalbot PPankow JFKhachatoorian CfalseTracing the movement of electronic cigarette flavor chemicals and nicotine from refill fluids to aerosol, lungs, exhale, and the environment.<h4>Background</h4>Given the high concentrations of nicotine and flavor chemicals in EC (electronic cigarette) fluids, it is important to determine how efficiently they transfer to aerosols, how well they are retained by users (exposure), and if they are exhaled into the environment where they settle of surfaces forming ECEAR (EC exhaled aerosol residue).<h4>Objectives</h4>To quantify the flavor chemicals and nicotine in refill fluids, inhaled aerosols, and exhaled aerosols. Then deduce their retention and contribution to ECEAR.<h4>Methods</h4>Flavor chemicals and nicotine were identified and quantified by GC-MS in two refill fluids, smoking machine-generated aerosols, and aerosols exhaled by 10 human participants (average age 21; 7 males). Machine generated aerosols were made with varying2022-01-01T00:00:00Z2022 Jan2025-04-19T18:09:33.232Z2025-04-19T18:09:33.232ZS-EPMC87879413439219810.1016/j.chemosphere.2021.131494