biostudies-literatureEzekowitz JANCATS NIH HHSRoche DiagnosticsNational Heart, Lung, and Blood Institute77-86https://www.ebi.ac.uk/biostudies/studies/S-EPMC8787989biostudies-literatureUnknown9(1)<h4>Aims</h4>N-terminal pro-b-type natriuretic peptide (NT-proBNP) values may be influenced by patient factors beyond the severity of illness, including atrial fibrillation (AF), renal dysfunction, or increased body mass index (BMI). We hypothesized that these factors may influence the achievement of NT-proBNP targets and clinical outcomes.<h4>Methods</h4>A total of 894 patients with heart failure with reduced ejection fraction were enrolled in The Guiding Evidence-Based Therapy Using Biomarker Intensified Treatment trial. NT-proBNP was analysed every 3 months.<h4>Results</h4>Forty per cent of patients had AF, the median estimated glomerular filtration rate (eGFR) was 59 mL/min/1.73 m² [interquartile range (IQR) 43-76], and median BMI was 29 kg/m² (IQR 25-34). PatientESC heart failureThe influence of comorbidities on achieving an N-terminal pro-b-type natriuretic peptide target: a secondary analysis of the GUIDE-IT trial.PMC8787989UL1 TR001863Mark DO'Connor CMGrant ADFiuzat MAhmad TEzekowitz JAWhellan DJAdams KCooper LSLeifer ESPina ILJanuzzi JLRathwell SFelker GMAlemayehu WfalseThe influence of comorbidities on achieving an N-terminal pro-b-type natriuretic peptide target: a secondary analysis of the GUIDE-IT trial.<h4>Aims</h4>N-terminal pro-b-type natriuretic peptide (NT-proBNP) values may be influenced by patient factors beyond the severity of illness, including atrial fibrillation (AF), renal dysfunction, or increased body mass index (BMI). We hypothesized that these factors may influence the achievement of NT-proBNP targets and clinical outcomes.<h4>Methods</h4>A total of 894 patients with heart failure with reduced ejection fraction were enrolled in The Guiding Evidence-Based Therapy Using Biomarker Intensified Treatment trial. NT-proBNP was analysed every 3 months.<h4>Results</h4>Forty per cent of patients had AF, the median estimated glomerular filtration rate (eGFR) was 59 mL/min/1.73 m² [interquartile range (IQR) 43-76], and median BMI was 29 kg/m² (IQR 25-34). Patient2022-01-01T00:00:00Z2022 Feb2026-05-09T04:32:02.843Z2022-02-11T15:40:16.308ZS-EPMC87879893478465710.1002/ehf2.13692