biostudies-literatureUnknown2(5)Marumoto H<h4>Background</h4>Single-nephron dynamics in progressive IgA nephropathy (IgAN) have not been studied. We applied novel methodology to explore single-nephron parameters in IgAN.<h4>Methods</h4>Nonglobally sclerotic glomeruli (NSG) and globally sclerotic glomeruli (GSG) per kidney were estimated using cortical volume assessment <i>via</i> unenhanced computed tomography and biopsy-based stereology. Estimated single-nephron GFR (eSNGFR) and single-nephron urine protein excretion (SNUPE) were calculated by dividing eGFR and UPE by the number of NSG. Associations with CKD stage and clinicopathologic findings were cross-sectionally investigated.<h4>Results</h4>This study included 245 patients with IgAN (mean age 43 years, 62% male, 45% on renin-angiotensin aldosterone system [RAAS] inhibitors pKidney360828-841https://www.ebi.ac.uk/biostudies/studies/S-EPMC8791345biostudies-literatureTotal Nephron Number and Single-Nephron Parameters in Patients with IgA Nephropathy.PMC8791345Kanzaki GRule ADYokoo TMarumoto HSasaki TKawamura TShimizu AHaruhara KD'Agati VDBertram JFTsuboi NKoike KOkabayashi YfalseTotal Nephron Number and Single-Nephron Parameters in Patients with IgA Nephropathy.<h4>Background</h4>Single-nephron dynamics in progressive IgA nephropathy (IgAN) have not been studied. We applied novel methodology to explore single-nephron parameters in IgAN.<h4>Methods</h4>Nonglobally sclerotic glomeruli (NSG) and globally sclerotic glomeruli (GSG) per kidney were estimated using cortical volume assessment <i>via</i> unenhanced computed tomography and biopsy-based stereology. Estimated single-nephron GFR (eSNGFR) and single-nephron urine protein excretion (SNUPE) were calculated by dividing eGFR and UPE by the number of NSG. Associations with CKD stage and clinicopathologic findings were cross-sectionally investigated.<h4>Results</h4>This study included 245 patients with IgAN (mean age 43 years, 62% male, 45% on renin-angiotensin aldosterone system [RAAS] inhibitors p2021-01-01T00:00:00Z2021 May2025-04-04T07:47:53.731Z2025-04-04T07:47:53.731ZS-EPMC87913453537306310.34067/KID.000697202010.34067/kid.0006972020