{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tice AL"],"funding":["HHS | NIH | National Institute on Alcohol Abuse and Alcoholism","HHS | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA)","NIAMS NIH HHS"],"pagination":["E606-E620"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8791790"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["321(5)"],"pubmed_abstract":["Circadian rhythms are central to optimal physiological function, as disruption contributes to the development of several chronic diseases. Alcohol (EtOH) intoxication disrupts circadian rhythms within liver, brain, and intestines, but it is unknown whether alcohol also disrupts components of the core clock in skeletal muscle. Female C57BL/6Hsd mice were randomized to receive either saline (control) or alcohol (EtOH) (5 g/kg) via intraperitoneal injection at the start of the dark cycle [<i>Zeitgeber time (ZT12)</i>], and gastrocnemius was collected every 4 h from control and EtOH-treated mice for the next 48 h following isoflurane anesthetization. In addition, metyrapone was administered before alcohol intoxication in separate mice to determine whether the alcohol-induced increase in serum "],"journal":["American journal of physiology. Endocrinology and metabolism"],"pubmed_title":["Binge alcohol disrupts skeletal muscle core molecular clock independent of glucocorticoids."],"pmcid":["PMC8791790"],"funding_grant_id":["AA11290","R01 AR079220"],"pubmed_authors":["Laudato JA","Lee C","Vied C","Steiner JL","Rossetti ML","Esser KA","Lang CH","Wolff CA","Tice AL","Gordon BS"],"additional_accession":[]},"is_claimable":false,"name":"Binge alcohol disrupts skeletal muscle core molecular clock independent of glucocorticoids.","description":"Circadian rhythms are central to optimal physiological function, as disruption contributes to the development of several chronic diseases. Alcohol (EtOH) intoxication disrupts circadian rhythms within liver, brain, and intestines, but it is unknown whether alcohol also disrupts components of the core clock in skeletal muscle. Female C57BL/6Hsd mice were randomized to receive either saline (control) or alcohol (EtOH) (5 g/kg) via intraperitoneal injection at the start of the dark cycle [<i>Zeitgeber time (ZT12)</i>], and gastrocnemius was collected every 4 h from control and EtOH-treated mice for the next 48 h following isoflurane anesthetization. In addition, metyrapone was administered before alcohol intoxication in separate mice to determine whether the alcohol-induced increase in serum ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2025-04-04T22:33:26.61Z","creation":"2025-02-19T03:24:02.989Z"},"accession":"S-EPMC8791790","cross_references":{"pubmed":["34541876"],"doi":["10.1152/ajpendo.00187.2021"]}}