{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rudra S"],"funding":["NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","NIH"],"pagination":["1408-1410.e2"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8792097"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(6)"],"pubmed_abstract":["Very early onset inflammatory bowel disease (VEO-IBD), diagnosed <6 years old, can be genetically and phenotypically distinct and more refractory than older-onset IBD. Identified causal monogenic defects have been targeted therapeutically in a small subset of VEO-IBD<sup>1</sup>; however, for most of these children, treatment strategies, such as phenotypic profiles, are critically needed to improve outcomes."],"journal":["Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association"],"pubmed_title":["Ruxolitinib: Targeted Approach for Treatment of Autoinflammatory Very Early Onset Inflammatory Bowel Disease."],"pmcid":["PMC8792097"],"funding_grant_id":["R01 DK111843","K23 DK119585","R01 DK127044"],"pubmed_authors":["Shaul E","Patel T","Dawany N","Sullivan KE","Moore A","Conrad M","Behrens E","Canavan MC","Kelsen JR","Rudra S"],"additional_accession":[]},"is_claimable":false,"name":"Ruxolitinib: Targeted Approach for Treatment of Autoinflammatory Very Early Onset Inflammatory Bowel Disease.","description":"Very early onset inflammatory bowel disease (VEO-IBD), diagnosed <6 years old, can be genetically and phenotypically distinct and more refractory than older-onset IBD. Identified causal monogenic defects have been targeted therapeutically in a small subset of VEO-IBD<sup>1</sup>; however, for most of these children, treatment strategies, such as phenotypic profiles, are critically needed to improve outcomes.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-18T17:46:56.312Z","creation":"2025-04-07T05:20:47.065Z"},"accession":"S-EPMC8792097","cross_references":{"pubmed":["34329777"],"doi":["10.1016/j.cgh.2021.07.040"]}}