{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["DiCarlo GE"],"funding":["NICHD NIH HHS","NIMH NIH HHS","National Institutes of Health","NIGMS NIH HHS"],"pagination":["104494"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8792250"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["133"],"pubmed_abstract":["Autism Spectrum Disorder (ASD) is a highly heterogeneous neurodevelopmental disorder characterized by deficits in social communication and by patterns of restricted interests and/or repetitive behaviors. The Simons Foundation Autism Research Initiative's Human Gene and CNV Modules now list over 1000 genes implicated in ASD and over 2000 copy number variant loci reported in individuals with ASD. Given this ever-growing list of genetic changes associated with ASD, it has become evident that there is likely not a single genetic cause of this disorder nor a single neurobiological basis of this disorder. Instead, it is likely that many different neurobiological perturbations (which may represent subtypes of ASD) can result in the set of behavioral symptoms that we called ASD. One such of possib"],"journal":["Neuroscience and biobehavioral reviews"],"pubmed_title":["Modeling dopamine dysfunction in autism spectrum disorder: From invertebrates to vertebrates."],"pmcid":["PMC8792250"],"funding_grant_id":["F30MH115535","P50 HD103537","F30 MH115535","T32GM007347","P50HD103537","T32 GM007347"],"pubmed_authors":["DiCarlo GE","Wallace MT"],"additional_accession":[]},"is_claimable":false,"name":"Modeling dopamine dysfunction in autism spectrum disorder: From invertebrates to vertebrates.","description":"Autism Spectrum Disorder (ASD) is a highly heterogeneous neurodevelopmental disorder characterized by deficits in social communication and by patterns of restricted interests and/or repetitive behaviors. The Simons Foundation Autism Research Initiative's Human Gene and CNV Modules now list over 1000 genes implicated in ASD and over 2000 copy number variant loci reported in individuals with ASD. Given this ever-growing list of genetic changes associated with ASD, it has become evident that there is likely not a single genetic cause of this disorder nor a single neurobiological basis of this disorder. Instead, it is likely that many different neurobiological perturbations (which may represent subtypes of ASD) can result in the set of behavioral symptoms that we called ASD. One such of possib","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-19T14:19:26.859Z","creation":"2025-02-19T04:46:16.735Z"},"accession":"S-EPMC8792250","cross_references":{"pubmed":["34906613"],"doi":["10.1016/j.neubiorev.2021.12.017"]}}