{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Snarski P"],"funding":["NHLBI NIH HHS"],"pagination":["113-126"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8792341"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["42(2)"],"pubmed_abstract":["<h4>Objective</h4>IGF-1 (insulin-like growth factor 1) exerts pleiotropic effects including promotion of cellular growth, differentiation, survival, and anabolism. We have shown that systemic IGF-1 administration reduced atherosclerosis in Apoe<sup>-/</sup><sup>-</sup> (apolipoprotein E deficient) mice, and this effect was associated with a reduction in lesional macrophages and a decreased number of foam cells in the plaque. Almost all cell types secrete IGF-1, but the effect of macrophage-derived IGF-1 on the pathogenesis of atherosclerosis is poorly understood. We hypothesized that macrophage-derived IGF-1 will reduce atherosclerosis. Approach and Results: We created macrophage-specific IGF-1 overexpressing mice on an Apoe<sup>-</sup><sup>/</sup><sup>-</sup> background. Macrophage-specif"],"journal":["Arteriosclerosis, thrombosis, and vascular biology"],"pubmed_title":["Macrophage-Specific IGF-1 Overexpression Reduces CXCL12 Chemokine Levels and Suppresses Atherosclerotic Burden in Apoe-Deficient Mice."],"pmcid":["PMC8792341"],"funding_grant_id":["R01 HL142796","R01 HL070241"],"pubmed_authors":["Sukhanov S","Danchuk S","Higashi Y","Chandrasekar B","Yoshida T","Snarski P","Rivera-Lopez V","Tian D","Delafontaine P"],"additional_accession":[]},"is_claimable":false,"name":"Macrophage-Specific IGF-1 Overexpression Reduces CXCL12 Chemokine Levels and Suppresses Atherosclerotic Burden in Apoe-Deficient Mice.","description":"<h4>Objective</h4>IGF-1 (insulin-like growth factor 1) exerts pleiotropic effects including promotion of cellular growth, differentiation, survival, and anabolism. We have shown that systemic IGF-1 administration reduced atherosclerosis in Apoe<sup>-/</sup><sup>-</sup> (apolipoprotein E deficient) mice, and this effect was associated with a reduction in lesional macrophages and a decreased number of foam cells in the plaque. Almost all cell types secrete IGF-1, but the effect of macrophage-derived IGF-1 on the pathogenesis of atherosclerosis is poorly understood. We hypothesized that macrophage-derived IGF-1 will reduce atherosclerosis. Approach and Results: We created macrophage-specific IGF-1 overexpressing mice on an Apoe<sup>-</sup><sup>/</sup><sup>-</sup> background. Macrophage-specif","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-05T09:04:52.865Z","creation":"2025-04-05T09:04:52.865Z"},"accession":"S-EPMC8792341","cross_references":{"pubmed":["34852642"],"doi":["10.1161/ATVBAHA.121.316090","10.1161/atvbaha.121.316090"]}}