biostudies-literatureSnarski PNHLBI NIH HHS113-126https://www.ebi.ac.uk/biostudies/studies/S-EPMC8792341biostudies-literatureUnknown42(2)<h4>Objective</h4>IGF-1 (insulin-like growth factor 1) exerts pleiotropic effects including promotion of cellular growth, differentiation, survival, and anabolism. We have shown that systemic IGF-1 administration reduced atherosclerosis in Apoe^-/^- (apolipoprotein E deficient) mice, and this effect was associated with a reduction in lesional macrophages and a decreased number of foam cells in the plaque. Almost all cell types secrete IGF-1, but the effect of macrophage-derived IGF-1 on the pathogenesis of atherosclerosis is poorly understood. We hypothesized that macrophage-derived IGF-1 will reduce atherosclerosis. Approach and Results: We created macrophage-specific IGF-1 overexpressing mice on an Apoe^-^/^- background. Macrophage-specifArteriosclerosis, thrombosis, and vascular biologyMacrophage-Specific IGF-1 Overexpression Reduces CXCL12 Chemokine Levels and Suppresses Atherosclerotic Burden in Apoe-Deficient Mice.PMC8792341R01 HL142796R01 HL070241Sukhanov SDanchuk SHigashi YChandrasekar BYoshida TSnarski PRivera-Lopez VTian DDelafontaine PfalseMacrophage-Specific IGF-1 Overexpression Reduces CXCL12 Chemokine Levels and Suppresses Atherosclerotic Burden in Apoe-Deficient Mice.<h4>Objective</h4>IGF-1 (insulin-like growth factor 1) exerts pleiotropic effects including promotion of cellular growth, differentiation, survival, and anabolism. We have shown that systemic IGF-1 administration reduced atherosclerosis in Apoe^-/^- (apolipoprotein E deficient) mice, and this effect was associated with a reduction in lesional macrophages and a decreased number of foam cells in the plaque. Almost all cell types secrete IGF-1, but the effect of macrophage-derived IGF-1 on the pathogenesis of atherosclerosis is poorly understood. We hypothesized that macrophage-derived IGF-1 will reduce atherosclerosis. Approach and Results: We created macrophage-specific IGF-1 overexpressing mice on an Apoe^-^/^- background. Macrophage-specif2022-01-01T00:00:00Z2022 Feb2025-04-05T09:04:52.865Z2025-04-05T09:04:52.865ZS-EPMC87923413485264210.1161/ATVBAHA.121.31609010.1161/atvbaha.121.316090